Indirect presynaptic modulation of striatal dopamine release by GABAB receptors in the rat substantia nigra

被引：9

作者：

Balon, N

Kriem, B

Weiss, M

Rostain, JC ^{[1
]}

机构：

[1] Univ Mediterranee, F-13916 Marseille 20, France

[2] IFR Jean Roche, Fac Med Nord, Lab Physiopathol & Act Therapeut Gaz Sous Press, EA 3280,IMNSSA, F-13916 Marseille, France

来源：

NEUROSCIENCE LETTERS | 2002年 / 325卷 / 01期

关键词：

gamma-aminobutyric acid; 5-aminovaleric acid; baclofen; voltammetry;

D O I：

10.1016/S0304-3940(02)00226-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regulation of striatal dopamine release by gamma-aminobutyric acid (GABA) neurotransmission was investigated using voltammetry in freely moving rats, following focal injection of the GABA(B) receptor agonist baclofen or the GABA(B) receptor antagonist 5-aminovaleric acid (5-AVA) in either the substantia nigra pars reticulata (SNr) or the substantia nigra pars compacta (SNc). Administration in the SNr of baclofen and 5-AVA at the dose of 2 pg, but not of 0.2 pg, resulted in a decrease and an increase in striatal dopamine release, respectively. In contrast, when injected in the SNc, 5-AVA only produced a transient increase in striatal dopamine release, while baclofen remained ineffective. This suggests that GABA(B) receptors in the SNr, but not the SNc, may play a major role in the control of nigrostriatal dopamine (DA) activity and the release of DA in the striatum. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：33 / 36

页数：4

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