When the Clock stops ticking, metabolic syndrome explodes

被引：112

作者：

Staels, B ^{[1
]}

机构：

[1] Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France

[2] INSERM, U545, F-59019 Lille, France

[3] Univ Lille 2, F-59006 Lille, France

来源：

NATURE MEDICINE | 2006年 / 12卷 / 01期

关键词：

D O I：

10.1038/nm0106-54

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circadian control depends on oscillating transcription factors, master switches synchronized by stimuli such as light and feeding. Recent studies show that altering circadian rhythmicity also results in pathophysiological changes resembling the metabolic syndrome.

引用

页码：54 / 55

页数：2

共 20 条

[1] The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1
Akashi, M
Takumi, T
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (05) : 441 - 448
[2] Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue
Ando, H
Yanagihara, H
Hayashi, Y
Obi, Y
Tsuruoka, S
Takamura, T
Kaneko, S
Fujimura, A
[J]. ENDOCRINOLOGY, 2005, 146 (12) : 5631 - 5636
[3] Relation between circadian patterns in levels of circulating lipoprotein(a), fibrinogen, platelets, and related lipid variables in men
Bremner, WF
Sothern, RB
Kanabrocki, EL
Ryan, M
McCormick, JB
Dawson, S
Connors, ES
Rothschild, R
Third, JLHC
Vahed, S
Nemchausky, BM
Shirazi, P
Olwin, JH
[J]. AMERICAN HEART JOURNAL, 2000, 139 (01) : 164 - 173
[4] Circadian clock and microarrays: mammalian genome gets rhythm
Delaunay, F
Laudet, V
[J]. TRENDS IN GENETICS, 2002, 18 (12) : 595 - 597
[5] The orphan nuclear receptor Rev-Erbα is a peroxisome proliferator-activated receptor (PPAR) γ target gene and promotes PPAR γ-induced adipocyte differentiation
Fontaine, C
Dubois, G
Duguay, Y
Helledie, T
Vu-Dac, N
Gervois, P
Soncin, F
Mandrup, S
Fruchart, JC
Fruchart-Najib, J
Staels, B
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) : 37672 - 37680
[6] Fibrates increase human REV-ERBα expression in liver via a novel peroxisome proliferator-activated receptor response element
Gervois, P
Chopin-Delannoy, S
Fadel, A
Dubois, G
Kosykh, V
Fruchart, JC
Najïb, J
Laudet, V
Staels, B
[J]. MOLECULAR ENDOCRINOLOGY, 1999, 13 (03) : 400 - 409
[7] Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors
Guillaumond, F
Dardente, H
Giguère, V
Cermakian, N
[J]. JOURNAL OF BIOLOGICAL RHYTHMS, 2005, 20 (05) : 391 - 403
[8] Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people
Karlsson, B
Knutsson, A
Lindahl, B
[J]. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2001, 58 (11) : 747 - 752
[9] LEE YH, 1994, J BIOL CHEM, V269, P14681
[10] Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm
Lemberger, T
Saladin, R
Vazquez, M
Assimacopoulos, F
Staels, B
Desvergne, B
Wahli, W
Auwerx, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) : 1764 - 1769

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