Lymphatic abnormalities in the normal contralateral arms of subjects with breast cancer-related lymphedema as assessed by near-infrared fluorescent imaging

被引：48

作者：

Aldrich, Melissa B. ^{[1
]}

Guilliod, Renie ^{[2
]}

Fife, Caroline E. ^{[2
]}

Maus, Erik A. ^{[2
]}

Smith, Latisha ^{[2
]}

Rasmussen, John C. ^{[1
]}

Sevick-Muraca, Eva M. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Ctr Mol Imaging, Houston, TX 77030 USA

[2] Mem Hermann Hosp, Mem Hermann Ctr Wound Healing, Houston, TX 77030 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

LOWER-LIMB LYMPHEDEMA; NODE DISSECTION; RISK-FACTORS; MELANOMA; LYMPHOGRAPHY; HEALTHY; TRIAL;

D O I：

10.1364/BOE.3.001256

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Current treatment of unilateral breast cancer-related lymphedema (BCRL) is only directed to the afflicted arm. Near-infrared fluorescent imaging (NIRF) of arm lymphatic vessel architecture and function in BCRL and control subjects revealed a trend of increased lymphatic abnormalities in both the afflicted and unafflicted arms with increasing time after lymphedema onset. These pilot results show that BCRL may progress to affect the clinically "normal" arm, and suggest that cancer-related lymphedema may become a systemic, rather than local, malady. These findings support further study to understand the etiology of cancer-related lymphedema and lead to better diagnostics and therapeutics directed to the systemic lymphatic system. (C) 2012 Optical Society of America

引用

页码：1256 / 1265

页数：10

共 38 条

[1]

Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema [J].