Gabapentin does not affect antipyrine clearance

被引：5

作者：

Allen, E

Tsanaclis, LM

Wroe, SJ

Reece, PA

Sedman, AJ

机构：

[1] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Dept Clin Pharmacol, Ann Arbor, MI 48105 USA

[2] Guys Drug Res Unit, London, England

[3] BioDynam Res Ltd, Cardiff, S Glam, Wales

[4] Ipswich Hosp, Dept Clin Neurol, Ipswich, Suffolk, England

[5] Biota Holdings Ltd, Melbourne, Vic, Australia

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1999年 / 39卷 / 09期

关键词：

D O I：

10.1177/00912709922008551

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of gabapentin on antipyrine clearance was assessed in 12 healthy male volunteers, using a known enzyme inducer, phenytoin, as control. Subjects received gabapentin 400 mg or phenytoin 100 mg three times daily for 2 weeks. Antipyrine tests were performed before, during, and after treatment with gabapentin or phenytoin. In contrast to phenytoin, chronic administration of gabapentin did not affect antipyrine clearance. Gabapentin appears to have little potential for drug interactions. Journal of Clinical Pharmacology, 1999;39:934-935 (C) 1999 the American College of Clinical Pharmacology.

引用

页码：934 / 935

页数：2

共 10 条

[1] Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydromethylantipyrine, and norantipyrine formation [J].