Mastitis and immunological factors in breast milk of lactating women in Malawi

被引:62
作者
Semba, RD
Kumwenda, N
Taha, TE
Hoover, DR
Lan, Y
Eisinger, W
Mtimavalye, L
Broadhead, R
Miotti, PG
Van der Hoeven, L
Chiphangwi, JD
机构
[1] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[3] Univ Malawi, Coll Med, Dept Obstet & Gynaecol, Blantyre, Malawi
[4] Univ Malawi, Coll Med, Dept Paediat & Child Hlth, Blantyre, Malawi
关键词
D O I
10.1128/CDLI.6.5.671-674.1999
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although an elevated sodium concentration in human milk is suggested to be an indicator of mastitis, it is unclear whether elevated sodium concentrations are associated with immunological and inflammatory mediators in human milk We conducted a cross-sectional study to evaluate the relationships between elevated breast milk sodium concentrations and levels of lactoferrin, lysozyme, secretory leukocyte protease inhibitor (SLPI), interleukin-1 (IL-8), and RANTES (regulated on activation normal T cell expressed and secreted) in human milk at 6 weeks postpartum in 96 lactating women in Blantyre, Malawi. Mastitis, as indicated by an elevated breast milk sodium concentration, was present in 15.6% of the women. Women with and without mastitis had respective median levels of other factors as follows: lactoferrin, 1,230 versus 565 mg/liter (P < 0.0007); lysozyme, 266 versus 274 mg/liter (P = 0.55); SLPI, 76 versus 15 mu g/liter, (P < 0.0002); IL-8, 339 versus 25 ng/liter (P < 0.0001); and RANTES, 82 versus 3 ng/liter (P < 0.0001). Elevated sodium concentrations in breast milk are associated with an increase in levels of some immunological and inflammatory factors in breast milk.
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页码:671 / 674
页数:4
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