miRNA regulation of cytokine genes

被引：133

作者：

Asirvatham, Ananthi J. ^{[1
]}

Magner, William J. ^{[1
]}

Tomasi, Thomas B. ^{[1
,2
,3
]}

机构：

[1] Roswell Pk Canc Inst, Mol Med Lab, Dept Immunol, Buffalo, NY 14263 USA

[2] SUNY Buffalo, Sch Med & Biomed Sci, Dept Med, Buffalo, NY 14214 USA

[3] SUNY Buffalo, Sch Med & Biomed Sci, Dept Microbiol & Immunol, Buffalo, NY 14214 USA

来源：

CYTOKINE | 2009年 / 45卷 / 02期

关键词：

miRNA; ARE; Cytokine; Chemokine; Evolution; MESSENGER-RNA STABILITY; TUMOR-NECROSIS-FACTOR; TRANSFORMING-GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; AU-RICH ELEMENTS; NF-KAPPA-B; VIRUS-INDUCED LYMPHOMAS; TGF-BETA; POSTTRANSCRIPTIONAL REGULATION; HUMAN CANCER;

D O I：

10.1016/j.cyto.2008.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：58 / 69

页数：12

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