Racemization of an L-phenylalanine residue catalysed by an adjacent cysteine in a bradykinin peptide antagonist

被引：3

作者：

Brown, C ^{[1
]}

Cutler, P ^{[1
]}

Eckers, C ^{[1
]}

Neville, W ^{[1
]}

Okafo, G ^{[1
]}

Camilleri, P ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

ANALYTICAL COMMUNICATIONS | 1996年 / 33卷 / 12期

关键词：

D O I：

10.1039/ac9963300433

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A number of peptides and proteins contain aromatic amino acid residues adjacent to a cysteine group in their primary sequence, Analysis of the ratios of D- to L-phenylalanine residues in some bradykinin antagonists has revealed that racemization occurs during conventional strong acid hydrolysis of the parent peptides. The mechanism for this unusual transformation appears to involve intramolecular catalysis by an adjacent cysteine residue.

引用

页码：433 / 436

页数：4

共 7 条

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