Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats

被引：79

作者：

Hu, Ji-Hua ^{[1
]}

Zheng, Xiao-Yan ^{[1
]}

Yang, Jian-Ping ^{[1
]}

Wang, Li-Na ^{[1
]}

Ji, Fu-Hai ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Anesthesiol, Suzhou 215006, Jiangsu, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 517卷 / 01期

关键词：

Cancer induced bone pain; MCP-1; CCR2; Chemokine; Rat; PERIPHERAL-NERVE INJURY; NEUROPATHIC PAIN; CHEMOKINE RECEPTOR; SENSORY NEURONS; EXPRESSION; CORD; CCR2; MODEL; ACTIVATION; CCL2;

D O I：

10.1016/j.neulet.2012.04.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In this study, we examined the involvement of chemokine monocyte chemoattractant protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain (CIBP). In this model. CIBP was established by an intramedullary injection of Walker 256 cells into the tibia of rats. We observed a significant increase in expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, an intrathecal injection of exogenous recombinant MCP-1 induced a striking mechanical allodynia in naive rats. These results suggest that increases in spinal MCP-1 and CCR2 expression are involved in the development of mechanical allodynia associated with bone cancer rats. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

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页码：60 / 63

页数：4

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