Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy

被引：77

作者：

Naccache, JM

Antoine, M

Wislez, M

Fleury-Feith, J

Oksenhendler, E

Mayaud, C

Cadranel, J

机构：

[1] Hop Tenon, Serv Pneumol & Reanimat Resp, F-75020 Paris, France

[2] Hop Tenon, Serv Anat Pathol, F-75020 Paris, France

[3] Hop Tenon, Serv Histol Biol Tumorale, F-75020 Paris, France

[4] Hop St Louis, Serv Immunohematol, F-75475 Paris, France

[5] Univ Paris 06, UFR St Antoine, Lab Biol & Immunopathol Pulm, UPRES EA 1531, Paris, France

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 1999年 / 159卷 / 06期

关键词：

D O I：

10.1164/ajrccm.159.6.9807152

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We report two cases of HIV-infected patients who presented with diffuse interstitial micronodular lesions on chest X-ray after institution of protease inhibitor-containing highly active antiretroviral therapy (HAART). Granulomatous pulmonary disorder mimicking sarcoidosis was diagnosed on histopathological studies revealing noncaseating granuloma and bronchoalveolar lavage analysis showing an intense CD4(+) lymphocyte alveolitis. Causative agents such as infectious organisms and environmental compounds were excluded. The relationship between sarcoid-like reaction and immune reconstitution under HAART is discussed.

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页码：2009 / 2013

页数：5

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