Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives

被引：27

作者：

Besson, C

Amiel, C

Le-Pendeven, C

Brice, P

Fermé, C

Carde, P

Hermine, O

Raphael, M

Abel, L ^{[1
]}

Nicolas, JC

机构：

[1] Univ Paris Rene Descartes, INSERM, U550, Fac Necker,Lab Genet Humaine Maladies Infect, F-75015 Paris, France

[2] Hop Bicetre, Serv Hematol Immunol Biol, Le Kremlin Bicetre, France

[3] Hop Tenon, Lab Virol, Paris, France

[4] Hop St Louis, Serv Oncohematol, Paris, France

[5] Inst Gustave Roussy, Dept Hematol, Paris, France

[6] Hop Necker Enfants Malad, Serv Hematol Adultes, Paris, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 01期

关键词：

D O I：

10.1128/JCM.44.1.47-50.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type I or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.

引用

页码：47 / 50

页数：4

共 22 条

[1] Routine use of real-time quantitative PCR for laboratory diagnosis of Epstein-Barr virus infections [J].

Brengel-Pesce, K ;

Morand, P ;

Schmuck, A ;

Bourgeat, MJ ;

Buisson, M ;

Barguès, G ;

Bouzid, M ;

Seigneurin, JM .

JOURNAL OF MEDICAL VIROLOGY, 2002, 66 (03) :360-369

[2]

Dehee A, 2001, J MED VIROL, V65, P543, DOI 10.1002/jmv.2071

[3] EPIDEMIOLOGICAL EVIDENCE FOR CAUSAL RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS AND BURKITTS-LYMPHOMA FROM UGANDAN PROSPECTIVE-STUDY [J].

DETHE, G ;

GESER, A ;

DAY, NE ;

TUKEI, PM ;

WILLIAMS, EH ;

BERI, DP ;

SMITH, PG ;

DEAN, AG ;

BORNKAMM, GW ;

FEORINO, P ;

HENLE, W .

NATURE, 1978, 274 (5673) :756-761

[4]

Drouet E, 1999, J MED VIROL, V57, P383, DOI 10.1002/(SICI)1096-9071(199904)57:4&lt

[5]

383::AID-JMV10&gt

[6]

3.0.CO

[7]

2-3

[8] Epstein-Barr viral load as a marker of lymphoma in AIDS patients [J].

Fan, HX ;

Kim, SC ;

Chima, CO ;

Israel, BF ;

Lawless, KM ;

Eagan, PA ;

Elmore, S ;

Moore, DT ;

Schichman, SA ;

Swinnen, LJ ;

Gulley, ML .

JOURNAL OF MEDICAL VIROLOGY, 2005, 75 (01) :59-69

[9]

Gallagher A, 1999, INT J CANCER, V84, P442, DOI 10.1002/(SICI)1097-0215(19990820)84:4<442::AID-IJC20>3.3.CO

[10]

2-A

← 1 2 3 →