t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia

被引：17

作者：

Ishida, F ^{[1
]}

Ueno, M

Tanaka, H

Makishima, H

Suzawa, K

Hosaka, S

Hidaka, E

Ishikawa, M

Yamauchi, K

Kitano, K

Kiyosawa, K

机构：

[1] Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 390, Japan

[2] Shinshu Univ, Sch Med, Cent Clin Lab, Matsumoto, Nagano 390, Japan

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 132卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(01)00550-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a male patient with acute myelogenous leukemia (AML; French-American-British M2) associated with AML 1-ETO. Cytogenetic studies showed a complex karyotype including a novel translocation (8;21;14)(q22;q22;q24) in all analyzed cells. This three-way translocation was confirmed with spectral karyotyping. Reverse transcription-polymerase chain reaction analysis for AML1-ETO chimeric transcripts showed the presence of the fusion product with the expected size. Translocation (8;21;14)(q22; q22;q24) is a novel variant of t(8;21)(q22;q22), possibly having a common molecular pathogenetic mechanism. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：133 / 135

页数：3

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