The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides

被引：17

作者：

Bourne, GT ^{[1
]}

Meutermans, WDF ^{[1
]}

Smythe, ML ^{[1
]}

机构：

[1] Univ Queensland, Ctr Drug Design & Dev, Brisbane, Qld 4072, Australia

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 40期

关键词：

secondary amine acylation; peptide synthesis; solid support;

D O I：

10.1016/S0040-4039(99)01473-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report on the solid phase synthesis of a backbone amide linker. The key step is the acylation of a secondary amide in quantitative yield. To show the application of this methodology we synthesised linear peptides CCK (25-33) and ACP (64-73) using Boc-based protocols in high yields and purity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7271 / 7274

页数：4

共 12 条

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