共 80 条
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p
被引:198
作者:

Stroupe, Christopher
论文数: 0 引用数: 0
h-index: 0
机构:
Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA

Collins, Kevin M.
论文数: 0 引用数: 0
h-index: 0
机构:
Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA

Fratti, Rutilio A.
论文数: 0 引用数: 0
h-index: 0
机构:
Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA

Wickner, William
论文数: 0 引用数: 0
h-index: 0
机构:
Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA
机构:
[1] Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA
关键词:
HOPS;
phosphoinositide;
PX;
Rab;
SNARE;
D O I:
10.1038/sj.emboj.7601051
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Coupling of Rab GTPase activation and SNARE complex assembly during membrane fusion is poorly understood. The homotypic fusion and vacuole protein sorting ( HOPS) complex links these two processes: it is an effector for the vacuolar Rab GTPase Ypt7p and is required for vacuolar SNARE complex assembly. We now report that pure, active HOPS complex binds phosphoinositides and the PX domain of the vacuolar SNARE protein Vam7p. These binding interactions support HOPS complex association with the vacuole and explain its enrichment at the same microdomains on docked vacuoles as phosphoinositides, Ypt7p, Vam7p, and the other SNARE proteins. Concentration of the HOPS complex at these microdomains may be a key factor for coupling Rab GTPase activation to SNARE complex assembly.
引用
收藏
页码:1579 / 1589
页数:11
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