Leptin, sympathetic nervous system, and baroreflex function

被引：37

作者：

Grassi, G ^{[1
]}

机构：

[1] Osped San Gerardo, Med Clin, I-20052 Monza, Milano, Italy

来源：

CURRENT HYPERTENSION REPORTS | 2004年 / 6卷 / 03期

关键词：

D O I：

10.1007/s11906-004-0075-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In addition to its direct effects on energy metabolism and caloric intake, leptin exerts several circulatory effects that appear to be mediated by an interaction with the sympathetic nervous system and the major reflexogenic area involved in cardiovascular homeostatic control-that is, the arterial baroreflex. In this paper, the relationships between the adipocyte hormone and the neuroadrenergic function are reviewed, taking into account data collected in experimental animal models as well as in human cardiovascular (hypertension and heart failure) and noncardiovascular (obesity) diseases that are characterized by a hyperadrenergic state coupled with a hyperleptinemia.

引用

页码：236 / 240

页数：5

共 41 条

[1] Leptin [J].

Ahima, RS ;

Flier, JS .

ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437

[2] PLASMA NOREPINEPHRINE AS A GUIDE TO PROGNOSIS IN PATIENTS WITH CHRONIC CONGESTIVE HEART-FAILURE [J].

COHN, JN ;

LEVINE, TB ;

OLIVARI, MT ;

GARBERG, V ;

LURA, D ;

FRANCIS, GS ;

SIMON, AB ;

RECTOR, T .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (13) :819-823

[3]

DELLORO R, 2001, J HYPERTENS S2, V19, pS102

[4] Interactions between leptin and the human sympathetic nervous system [J].

Eikelis, N ;

Schlaich, M ;

Aggarwal, A ;

Kaye, D ;

Esler, M .

HYPERTENSION, 2003, 41 (05) :1072-1079

[5] Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity [J].

El-Haschimi, K ;

Pierroz, DD ;

Hileman, SM ;

Bjorbæk, C ;

Flier, JS .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (12) :1827-1832

[6] Sympathetic nervous system activation in essential hypertension, cardiac failure and psychosomatic heart disease [J].

Esler, M ;

Kaye, D .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 35 :S1-S7

[7] OVERFLOW OF CATECHOLAMINE NEUROTRANSMITTERS TO THE CIRCULATION - SOURCE, FATE, AND FUNCTIONS [J].

ESLER, M ;

JENNINGS, G ;

LAMBERT, G ;

MEREDITH, I ;

HORNE, M ;

EISENHOFER, G .

PHYSIOLOGICAL REVIEWS, 1990, 70 (04) :963-985

[8] What's in a name? In search of leptin's physiologic role [J].

Flier, JS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (05) :1407-1413

[9] Role of the sympathetic nervous system in human hypertension [J].

Grassi, G .

JOURNAL OF HYPERTENSION, 1998, 16 (12) :1979-1987

[10] Heart rate as marker of sympathetic activity [J].

Grassi, G ;

Vailati, S ;

Bertinieri, G ;

Seravalle, G ;

Stella, ML ;

Dell'Oro, R ;

Mancia, G .

JOURNAL OF HYPERTENSION, 1998, 16 (11) :1635-1639

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