A magnetization transfer study of white matter in siblings of multiple sclerosis patients

被引：18

作者：

Filippi, M

Campi, A

Martino, G

Colombo, B

Comi, G

机构：

[1] UNIV MILAN,OSPED SAN RAFFAELE,DEPT NEURORADIOL,INST SCI,I-20132 MILAN,ITALY

[2] UNIV MILAN,OSPED SAN RAFFAELE,DEPT NEUROIMMUNOL,INST SCI,I-20132 MILAN,ITALY

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 147卷 / 02期

关键词：

multiple sclerosis; magnetization transfer; familial risk;

D O I：

10.1016/S0022-510X(96)05322-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study, we evaluated magnetization transfer ratio values in the brain white matter of siblings of multiple sclerosis (MS) patients and compared them to those obtained in sex- and age-matched normal controls. No statistically significant difference was found between the two groups for all the white matter areas studied (frontal and occipital lobes, centrum semiovale, periventricular white matter, internal capsule, genu and splenium of the corpus callosum). (C) 1997 Elsevier Science B.V.

引用

页码：151 / 153

页数：3

共 11 条

[1] MAGNETIC-RESONANCE RELAXATION-TIME MAPPING IN MULTIPLE-SCLEROSIS - NORMAL APPEARING WHITE-MATTER AND THE INVISIBLE LESION LOAD [J].

BARBOSA, S ;

BLUMHARDT, LD ;

ROBERTS, N ;

LOCK, T ;

EDWARDS, RHT .

MAGNETIC RESONANCE IMAGING, 1994, 12 (01) :33-42

[2]

DOUSSET V, 1995, AM J NEURORADIOL, V16, P225

[3] EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE-SCLEROSIS - LESION CHARACTERIZATION WITH MAGNETIZATION TRANSFER IMAGING [J].

DOUSSET, V ;

GROSSMAN, RI ;

RAMER, KN ;

SCHNALL, MD ;

YOUNG, LH ;

GONZALEZSCARANO, F ;

LAVI, E ;

COHEN, JA .

RADIOLOGY, 1992, 182 (02) :483-491

[4] A GENETIC-BASIS FOR FAMILIAL AGGREGATION IN MULTIPLE-SCLEROSIS [J].

EBERS, GC ;

SADOVNICK, AD ;

RISCH, NJ ;

BULMAN, D ;

RICE, GPA ;

HASHIMOTO, SA ;

PATY, D ;

OGER, JJF ;

METZ, L ;

BELL, R ;

WARREN, S ;

HADER, W ;

AUTY, T ;

NATH, A ;

GRAY, T ;

OCONNOR, P ;

NELSON, R ;

FREEDMAN, M ;

BRUNET, D ;

PAULSETH, R ;

FRANCIS, G ;

DUQUETTE, P ;

MURRAY, TJ ;

BAHN, V ;

PRYSEPHILLIPS, W .

NATURE, 1995, 377 (6545) :150-151

[5] A MAGNETIZATION-TRANSFER IMAGING STUDY OF NORMAL-APPEARING WHITE-MATTER IN MULTIPLE-SCLEROSIS [J].

FILIPPI, M ;

CAMPI, A ;

DOUSSET, V ;

BARATTI, C ;

MARTINELLI, V ;

CANAL, N ;

SCOTTI, G ;

COMI, G .

NEUROLOGY, 1995, 45 (03) :478-482

[6] CORRELATION OF MAGNETIZATION-TRANSFER RATIO WITH CLINICAL DISABILITY IN MULTIPLE-SCLEROSIS [J].

GASS, A ;

BARKER, GJ ;

KIDD, D ;

THORPE, JW ;

MACMANUS, D ;

BRENNAN, A ;

TOFTS, PS ;

THOMPSON, AJ ;

MCDONALD, WI ;

MILLER, DH .

ANNALS OF NEUROLOGY, 1994, 36 (01) :62-67

[7]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

[8] MICROSCOPIC DISEASE IN NORMAL-APPEARING WHITE-MATTER ON CONVENTIONAL MR-IMAGES IN PATIENTS WITH MULTIPLE-SCLEROSIS - ASSESSMENT WITH MAGNETIZATION-TRANSFER MEASUREMENTS [J].

LOEVNER, LA ;

GROSSMAN, RI ;

COHEN, JA ;

LEXA, FJ ;

KESSLER, D ;

KOLSON, DL .

RADIOLOGY, 1995, 196 (02) :511-515

[9] MYELIN IN MULTIPLE-SCLEROSIS IS DEVELOPMENTALLY IMMATURE [J].

MOSCARELLO, MA ;

WOOD, DD ;

ACKERLEY, C ;

BOULIAS, C .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :146-154

[10] GENETIC SUSCEPTIBILITY IN FAMILIAL MULTIPLE-SCLEROSIS NOT LINKED TO THE MYELIN BASIC-PROTEIN GENE [J].

ROSE, J ;

GERKEN, S ;

LYNCH, S ;

PISANI, P ;

VARVIL, T ;

OTTERUD, B ;

LEPPERT, M .

LANCET, 1993, 341 (8854) :1179-1181

← 1 2 →