Mesenchymal stem cells and cardiac repair

被引：90

作者：

Nesselmann, Catharina ^{[1
]}

Ma, Nan ^{[1
]}

Bieback, Karen ^{[2
]}

Wagner, Wolfgang ^{[3
]}

Ho, Anthony ^{[3
]}

Konttinen, Yrjo T. ^{[4
]}

Zhang, Hao ^{[5
,6
]}

Hinescu, Mihail E. ^{[7
,8
]}

Steinhoff, Gustav ^{[1
]}

机构：

[1] Univ Rostock, Dept Cardiac Surg, D-18057 Rostock, Germany

[2] Heidelberg Univ, Inst Transfus Med & Immunol, Med Fac Mannheim, German Red Cross Blood Donor Serv Baden Wurttembe, D-6900 Heidelberg, Germany

[3] Heidelberg Univ, Med Klin 5, D-6900 Heidelberg, Germany

[4] Biomedicum Helsinki, Helsinki, Finland

[5] Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China

[6] Chinese Acad Med Sci, Fuwai Hosp, Beijing, Peoples R China

[7] Carol Davila Univ Med & Pharm, Dept Cellular & Mol Med, Bucharest, Romania

[8] Victor Babes Natl Inst Pathol, Bucharest, Romania

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2008年 / 12卷 / 5B期

关键词：

mesenchymal stem cells; ICLCs; regenerative medicine; heart muscle; repair mechanisms; ex vivo cell manipulation;

D O I：

10.1111/j.1582-4934.2008.00457.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeutic potential. This review focuses on the mechanism of MSCs in cardiac repair, with emphasis on ex vivo manipulation.

引用

页码：1795 / 1810

页数：16

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