Ultrasensitivity in (supra)molecularly organized and crowded environments

被引：13

作者：

Aon, MA ^{[1
]}

Gomez-Casati, DF ^{[1
]}

Iglesias, AA ^{[1
]}

Cortassa, S ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, INTECH, IIB, Inst Tecnol Chascomus, RA-7130 Chascomus, BA, Argentina

来源：

CELL BIOLOGY INTERNATIONAL | 2001年 / 25卷 / 11期

关键词：

ultrasensitivity; signalling cascades; metabolic pathways; cytoskeleton; crowding;

D O I：

10.1006/cbir.2001.0804

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- Or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells. (C) 2001 Academic Press.

引用

页码：1091 / 1099

页数：9

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[2]

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[3]

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[4]

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