Structural requirement for axonal regeneration-promoting effect of polyamines in cultured rat hippocampal neurons

被引：9

作者：

Abe, K ^{[1
]}

Chu, PJ ^{[1
]}

Shirahata, A ^{[1
]}

Samejima, K ^{[1
]}

Saito, H ^{[1
]}

机构：

[1] JOSAI UNIV,FAC PHARMACEUT SCI,DEPT ANALYT CHEM,SAKADO,SAITAMA 35002,JAPAN

来源：

BRAIN RESEARCH | 1997年 / 766卷 / 1-2期

关键词：

polyamine; axotomy; neurite regeneration; structure-activity relationship; cultured hippocampal neuron;

D O I：

10.1016/S0006-8993(97)00750-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously found that spermine, spermidine and putrescine promote axonal regeneration following axotomy in cultured rat hippocampal neurons. In the present study, we investigated which part of the polyamine molecule is responsible for the regeneration-promoting effect. Testing the effects of several synthetic analogues revealed that the butanediamine moiety is essential for the activity and the terminal primary amines are necessary for full agonist activity. The structure-activity relationship indicates that the regeneration-promoting effects of polyamines are not associated with NMDA receptors. (C) 1997 Elsevier Science B.V.

引用

页码：281 / 284

页数：4

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