Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats

被引：14

作者：

Niyaz, Batur ^{[1
]}

Zhao, Kai-Liang ^{[1
]}

Liu, Li-Min ^{[2
]}

Chen, Chen ^{[1
]}

Deng, Wen-Hong ^{[1
]}

Zuo, Teng ^{[1
]}

Shi, Qiao ^{[1
]}

Wang, Wei-Xing ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Gen Surg, Wuhan 430060, Hubei, Peoples R China

[2] Ezhou Cent Hosp, Dept Gen Surg, Ezhou 436000, Hubei, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2013年 / 6卷 / 04期

关键词：

hyperlipidemia; acute pancreatitis; peroxisome proliferator activated receptor-gamma ligand; cytokine; ACTIVATED RECEPTOR-GAMMA; NECROSIS-FACTOR-ALPHA; INTERCELLULAR-ADHESION MOLECULE-1; SPINAL-CORD-INJURY; NF-KAPPA-B; PPAR-GAMMA; LUNG INJURY; AGONIST ROSIGLITAZONE; UP-REGULATION; MOUSE MODEL;

D O I：

10.3892/etm.2013.1255

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti-inflammatory effects. However, the mechanisms by which PPAR-gamma ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR-gamma ligand, on hyperlipidemia with SAP in a rat model. The hyperlipidemia was induced with a high-fat diet and SAP was induced by the administration of sodium taurocholate (TCA). The hyperlipidemia was shown to aggravate the severity of the sodium taurocholate-induced SAP. However, rosiglitazone demonstrated significant antihyperlipidemic and anti-inflammatory effects in the rats with high-lipid diet-induced hyperlipidemia and SAP.

引用

页码：989 / 994

页数：6

共 44 条

[1] Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma [J].

Babu, Suresh K. ;

Puddicombe, Sarah M. ;

Arshad, Hasan H. ;

Wilson, Susan J. ;

Ward, John ;

Gozzard, Neil ;

Higgs, Gerry ;

Holgate, Stephen T. ;

Davies, Donna E. .

CLINICAL IMMUNOLOGY, 2011, 140 (01) :18-25

[2] Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis [J].

Bassaganya-Riera, Josep ;

Viladomiu, Monica ;

Pedragosa, Mireia ;

De Simone, Claudio ;

Carbo, Adria ;

Shaykhutdinov, Rustem ;

Jobin, Christian ;

Arthur, Janelle C. ;

Corl, Benjamin A. ;

Vogel, Hans ;

Storr, Martin ;

Hontecillas, Raquel .

PLOS ONE, 2012, 7 (02)

[3] Upregulation of TNF-α-induced ICAM-1 surface expression by adenylate cyclase-dependent pathway in human endothelial cells [J].

Bernot, D ;

Peiretti, F ;

Canault, M ;

Juhan-Vague, I ;

Nalbone, G .

JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 202 (02) :434-441

[4] Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis [J].

Bjelik, Annamaria ;

Bereczki, Erika ;

Gonda, Szilvia ;

Juhasz, Anna ;

Rimanoczy, Agnes ;

Zana, Marianna ;

Csont, Tamas ;

Pakaski, Magdolna ;

Boda, Krisztina ;

Ferdinandy, Peter ;

Dux, Laszlo ;

Janka, Zoltan ;

Santha, Miklos ;

Kalman, Janos .

NEUROCHEMISTRY INTERNATIONAL, 2006, 49 (04) :393-400

[5] Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation [J].

Blanquart, C ;

Barbier, O ;

Fruchart, JC ;

Staels, B ;

Glineur, C .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 85 (2-5) :267-273

[6] PPAR-Gamma Agonist Rosiglitazone Attenuates the Inflammation Caused by Carrageenan in the Mouse Model of Pleurisy [J].

Buss, Ziliani da Silva ;

Medeiros, Yara S. ;

Froede, Tania S. .

INFLAMMATION, 2012, 35 (01) :280-288

[7]

Cai Qun, 2012, Zhongguo Dang Dai Er Ke Za Zhi, V14, P301

[8] PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-GAMMA - ADIPOSE-PREDOMINANT EXPRESSION AND INDUCTION EARLY IN ADIPOCYTE DIFFERENTIATION [J].

CHAWLA, A ;

SCHWARZ, EJ ;

DIMACULANGAN, DD ;

LAZAR, MA .

ENDOCRINOLOGY, 1994, 135 (02) :798-800

[9] Rosiglitazone Attenuates the Severity of Sodium Taurocholate-induced Acute Pancreatitis and Pancreatitis-associated Lung Injury [J].

Chen, Chen ;

Xu, Sheng ;

Wang, Wei-Xing ;

Ding, You-Ming ;

Yu, Kai-Huan ;

Wang, Bin ;

Chen, Xiao-Yan .

ARCHIVES OF MEDICAL RESEARCH, 2009, 40 (02) :79-88

[10] Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein [J].

Cuzzocrea, S ;

Pisano, B ;

Dugo, L ;

Ianaro, A ;

Britti, D ;

Patel, NSA ;

Paola, RD ;

Genovese, T ;

Di Rosa, M ;

Caputi, AP ;

Thiemermann, C .

INTENSIVE CARE MEDICINE, 2004, 30 (05) :951-956

← 1 2 3 4 5 →