Nucleosides.: IX.: Synthesis of purine N3,5′-cyclonucleosides and N3,5′-cyclo-2′,3′-seconucleosides via mitsunobu reaction as TIBO-like derivatives

被引：13

作者：

Chen, GS ^{[1
]}

Chen, CS ^{[1
]}

Chien, TC ^{[1
]}

Yeh, JY ^{[1
]}

Kuo, CC ^{[1
]}

Talekar, RS ^{[1
]}

Chern, JW ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Sect 1, Taipei 10764, Taiwan

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 1-2期

关键词：

TIBO; Mitsunobu reaction; N-3,5 '-cyclonucleoside; N-3,5 '-cyclo-2 ',3 '-seconucleoside; formycin B;

D O I：

10.1081/NCN-120027904

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mitsunobu reaction was applied to prepare, in one step, purine N-3,5'-cyclonucleosides 10a-d. A subsequent ring opening in the ribose moiety of the resultant N-3,5'-nucleosides by sodium periodate led to the corresponding N-3,5'-cyclo-2',3'- seconucleosides. These products consist of 5-, 6-, and 7-membered tricyclic system which is the basic skeleton of TIBO derivatives, known antiviral agents.

引用

页码：347 / 359

页数：13

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