Magnetic Tagging of Therapeutic Cells for MRI

被引：68

作者：

Budde, Matthew D. ^{[1
]}

Frank, Joseph A. ^{[1
]}

机构：

[1] NIH, Ctr Clin, Bethesda, MD 20892 USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2009年 / 50卷 / 02期

基金：

美国国家卫生研究院;

关键词：

molecular imaging; MRI; magnetic cellular tagging; immune cells; stem cells; MESENCHYMAL STEM-CELLS; IN-VIVO MRI; RESONANCE TRACKING; CELLULAR THERAPY; CONTRAST AGENT; NANOPARTICLES; REPORTER; MODEL; EXPRESSION; REJECTION;

D O I：

10.2967/jnumed.108.053546

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Transplantation of stem cells or immune cells has shown promise for the treatment of several diseases. Monitoring magnetically la beled cells with MRI has furthered our understanding of cellular migration and the pathophysiology of diseases in experimental models. These studies should pave the way for guiding clinical trials using cell-based therapies. This review briefly describes the various methods used to label and track cells with MRI and the potential for such methods to translate to human applications.

引用

页码：171 / 174

页数：4

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