Small artery remodeling and significance in the development of hypertension

被引:182
作者
Mulvany, MJ [1 ]
机构
[1] Aarhus Univ, Dept Pharmacol, DK-8000 Aarhus C, Denmark
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷
关键词
D O I
10.1152/nips.01366.2001
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The structure of the resistance vessels is altered (remodeled) in individuals with high blood pressure (essential hypertension). The structure is dependent not only on blood pressure but also on blood flow and hormonal environment. Vascular biology is providing increased knowledge of the mechanisms involved and thus contributing to our understanding of the pathophysiology of the disease.
引用
收藏
页码:105 / 109
页数:5
相关论文
共 20 条
  • [1] EVIDENCE FOR INCREASED MEDIA THICKNESS, INCREASED NEURONAL AMINE UPTAKE, AND DEPRESSED EXCITATION CONTRACTION COUPLING IN ISOLATED RESISTANCE VESSELS FROM ESSENTIAL HYPERTENSIVES
    AALKJAER, C
    HEAGERTY, AM
    PETERSEN, KK
    SWALES, JD
    MULVANY, MJ
    [J]. CIRCULATION RESEARCH, 1987, 61 (02) : 181 - 186
  • [2] RENAL AND NEPHRON HEMODYNAMICS IN SPONTANEOUSLY HYPERTENSIVE RATS
    ARENDSHORST, WJ
    BEIERWALTES, WH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 236 (03): : F246 - F251
  • [3] Bakker ENTP, 2000, AM J PHYSIOL-HEART C, V278, pH1233
  • [4] Vascular smooth muscle growth: Autocrine growth mechanisms
    Berk, BC
    [J]. PHYSIOLOGICAL REVIEWS, 2001, 81 (03) : 999 - 1030
  • [5] Smooth muscle cell changes during flow-related remodeling of rat mesenteric resistance arteries
    Buus, CL
    Pourageaud, F
    Fazzi, GE
    Janssen, G
    Mulvany, MJ
    De Mey, JGR
    [J]. CIRCULATION RESEARCH, 2001, 89 (02) : 180 - 186
  • [6] Effects of an angiotensin-converting enzyme inhibitor and a β-blocker on cerebral arteriolar dilatation in hypertensive rats
    Chillon, JM
    Baumbach, GL
    [J]. HYPERTENSION, 2001, 37 (06) : 1388 - 1393
  • [7] Location of resistance arteries
    Christensen, KL
    Mulvany, MJ
    [J]. JOURNAL OF VASCULAR RESEARCH, 2001, 38 (01) : 1 - 12
  • [8] Vasodilatation, not hypotension, improves resistance vessel design during treatment of essential hypertension: a literature survey
    Christensen, KL
    Mulvany, MJ
    [J]. JOURNAL OF HYPERTENSION, 2001, 19 (06) : 1001 - 1006
  • [9] Folkow B., 1956, Hypotensive Drugs, P163
  • [10] SMALL ARTERY STRUCTURE IN HYPERTENSION - DUAL PROCESSES OF REMODELING AND GROWTH
    HEAGERTY, AM
    AALKJAER, C
    BUND, SJ
    KORSGAARD, N
    MULVANY, MJ
    [J]. HYPERTENSION, 1993, 21 (04) : 391 - 397