Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics

被引：23

作者：

Petitou, M ^{[1
]}

Driguez, PA ^{[1
]}

Duchaussoy, P ^{[1
]}

机构：

[1] Sanofi Rech, Haemobiol Res Dept, F-31036 Toulouse, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00156-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1161 / 1166

页数：6

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