Statins and the risk of idiopathic venous thromboembolism

被引：59

作者：

Yang, CC

Jick, SS

Jick, H

机构：

[1] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 112, Taiwan

[2] Vet Gen Hosp Taipei, Natl Poison Ctr, Taipei 11217, Taiwan

[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2002年 / 53卷 / 01期

关键词：

HMG-CoA reductase inhibitor; idiopathic venous thromboembolism; lipid-lowering drug;

D O I：

10.1046/j.0306-5251.2001.01523.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims To evaluate the association between current statin use and the risk of idiopathic venous thromboembolism (VTE). Methods A population-based retrospective follow-up with a nested case-control analysis using the General Practice Research Database. Results There were 72 cases of idiopathic VTE. Using normolipidaemic nonuse as the reference group, the adjusted relative risks for idiopathic VTE for current/recent statin use, past statin use, past other lipid-lowering drug use, and hyperlipidaemic nonuse were 0.8 (0.3, 2.7), 2.4 (0.6, 10.0), 1.8 (0.4, 7.4), and 0.9 (0.4, 2.0) in the follow-up analysis, and were 1.1 (0.3, 4.3), 3.7 (0.6, 24.1), 2.0 (0.3, 11.6), and 0.4 (0.2, 1.2) in the case-control analysis. Conclusions Current statin use was not associated with a reduced risk of idiopathic VTE.

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收藏

页码：101 / 105

页数：5

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