Surface modification using cubic silsesquioxane ligands. Facile synthesis of water-soluble metal oxide nanoparticles

被引：57

作者：

Frankamp, BL

Fischer, NO

Hong, R

Srivastava, S

Rotello, VM ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[2] Univ Massachusetts, Mol & Cellular Biol Program, Amherst, MA 01003 USA

来源：

CHEMISTRY OF MATERIALS | 2006年 / 18卷 / 04期

关键词：

D O I：

10.1021/cm052205i

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The use of magnetic nanoparticles in biological applications is hampered by the lack of versatile methods to transfer them into aqueous solutions. Monolayer exchange using anionic octa(tetramethylammonium)polyhedral oligomeric silsesquioxane provides individual particles that are soluble in aqueous environments and possess excellent stability in biologically relevant pH ranges and salt concentrations. In addition, this surface exchange reaction proved to be general in nature, allowing facile functionalization of a variety of magnetic nanoparticles.

引用

收藏

页码：956 / 959

页数：4

相关论文

共 24 条

[1] Functionalisation of magnetic nanoparticles for applications in biomedicine [J].

Berry, CC ;

Curtis, ASG .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) :R198-R206

[2] Monolayer exchange chemistry of γ-Fe2O3 nanoparticles [J].

Boal, AK ;

Das, K ;

Gray, M ;

Rotello, VM .

CHEMISTRY OF MATERIALS, 2002, 14 (06) :2628-2636

[3] Nanoparticles in cancer therapy and diagnosis [J].

Brigger, I ;

Dubernet, C ;

Couvreur, P .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651

[4] Thiolation of maghemite nanoparticles by dimercaptosuccinic acid [J].

Fauconnier, N ;

Pons, JN ;

Roger, J ;

Bee, A .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1997, 194 (02) :427-433

[5] Inhibition of chymotrypsin through surface binding using nanoparticle-based receptors [J].

Fischer, NO ;

McIntosh, CM ;

Simard, JM ;

Rotello, VM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5018-5023

[6] Patterned Langmuir-Blodgett films of mondisperse nanoparticles of iron oxide using soft lithography [J].

Guo, QJ ;

Teng, XW ;

Rahman, S ;

Yang, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (03) :630-631

[7] Electromagnetic heating of breast tumors in interventional radiology:: In vitro and in vivo studies in human cadavers and mice [J].

Hilger, I ;

Andrä, W ;

Hergt, R ;

Hiergeist, R ;

Schubert, H ;

Kaiser, WA .

RADIOLOGY, 2001, 218 (02) :570-575

[8] Control of protein structure and function through surface recognition by tailored nanoparticle scaffolds [J].

Hong, R ;

Fischer, NO ;

Verma, A ;

Goodman, CM ;

Emrick, T ;

Rotello, VM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (03) :739-743

[9] Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process [J].

Hyeon, T ;

Lee, SS ;

Park, J ;

Chung, Y ;

Bin Na, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (51) :12798-12801

[10] Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fields in vitro [J].

Jordan, A ;

Wust, P ;

Scholz, R ;

Tesche, B ;

Fahling, H ;

Mitrovics, T ;

Vogl, T ;

CervosNavarro, J ;

Felix, R .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 1996, 12 (06) :705-722