Structural maintenance of chromosomes (SMC) proteins - Conserved molecular properties for multiple biological functions

被引：151

作者：

Strunnikov, AV

Jessberger, R

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

[2] NICHD, Lab Mol Embryol, NIH, Bethesda, MD USA

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1999年 / 263卷 / 01期

关键词：

SMC proteins; chromosome condensation; sister chromatid cohesion; DNA recombination; gene dosage compensation; chromatin dynamics; cell cycle;

D O I：

10.1046/j.1432-1327.1999.00509.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evolutionarily-conserved eukaryotic SMC (structural maintenance of chromosomes) proteins are ubiquitous chromosomal components in prokaryotes and eukaryotes. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. The two most prominent and best-characterized complexes an cohesin and condensin, necessary for sister chromatid cohesion and chromosome condensation. Hen we discuss these functions together with additional roles in gene dosage compensation and DNA recombination.

引用

页码：6 / 13

页数：8

共 73 条

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