Deep within the filarial genome: Progress of The Filarial Genome Project

被引:35
作者
Williams, SA [1 ]
Laney, SJ [1 ]
Bierwert, LA [1 ]
Lizotte-Waniewski, M [1 ]
Saunders, L [1 ]
Lu, WH [1 ]
Haynes, S [1 ]
Li, W [1 ]
Blaxter, ML [1 ]
Guiliano, D [1 ]
Daub, J [1 ]
Jayaraman, K [1 ]
Rao, RV [1 ]
Ravi, V [1 ]
Kaliraj, P [1 ]
Kannan, K [1 ]
Narayanan, RB [1 ]
Ramzy, RMR [1 ]
Kamal, IH [1 ]
Scott, AL [1 ]
Ghosh, I [1 ]
Raghavan, N [1 ]
Slatko, B [1 ]
Ware, J [1 ]
Foster, J [1 ]
Ganatra, M [1 ]
Supali, T [1 ]
机构
[1] Smith Coll, Clark Sci Ctr, Dept Biol Sci, Northampton, MA 01063 USA
来源
PARASITOLOGY TODAY | 1999年 / 15卷 / 06期
关键词
D O I
10.1016/S0169-4758(99)01454-4
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Four years ago, a WHO/United Nations Development Programme/World Bank-sponsored genome project to study the filarial lymphatic nematode parasite Brugia malayi was initiated. The project took as its aims gene discovery for drug target and vaccine candidate identification, genome mapping dissemination of genomic data to the world community and training of endemic country partners in genomic research. In this article, the principal investigators in the laboratories behind the project describe the background to the project, the data now emerging and goals for the future. Open access to filarial genome data is emphasized.
引用
收藏
页码:219 / 224
页数:6
相关论文
共 41 条
[1]  
[Anonymous], 1997, C ELEGANS
[2]   Phylogeny of Wolbachia in filarial nematodes [J].
Bandi, C ;
Anderson, TJC ;
Genchi, C ;
Blaxter, ML .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1998, 265 (1413) :2407-2413
[3]   Internet resources for the parasite genome projects [J].
Blaxter, M ;
Aslett, M .
TRENDS IN GENETICS, 1997, 13 (01) :40-41
[4]   A unified nomenclature for filarial genes [J].
Blaxter, ML ;
Guiliano, DB ;
Scott, AL ;
Williams, SA .
PARASITOLOGY TODAY, 1997, 13 (11) :416-417
[5]   Genes expressed in Brugia malayi infective third stage larvae [J].
Blaxter, ML ;
Raghavan, N ;
Ghosh, I ;
Guiliano, D ;
Lu, W ;
Williams, SA ;
Slatko, B ;
Scott, AL .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 77 (01) :77-93
[6]  
BLAXTER ML, 1995, PARASITOL TODAY, V11, P811
[7]  
BLUMENTHAL T, 1997, C ELEGANS, V2, P117
[8]   PROPHYLACTIC ACTIVITY OF TETRACYCLINE AGAINST BRUGIA-PAHANGI INFECTION IN JIRDS (MERIONES-UNGUICULATUS) [J].
BOSSHARDT, SC ;
MCCALL, JW ;
COLEMAN, SU ;
JONES, KL ;
PETIT, TA ;
KLEI, TR .
JOURNAL OF PARASITOLOGY, 1993, 79 (05) :775-777
[9]   Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].
不详 .
SCIENCE, 1998, 282 (5396) :2012-2018
[10]   Thioredoxin peroxidases from Brugia malayi [J].
Ghosh, I ;
Eisinger, SW ;
Raghavan, N ;
Scott, AL .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 91 (02) :207-220