The biochemistry of polyadenylation

被引：160

作者：

Wahle, E ^{[1
]}

Keller, W ^{[1
]}

机构：

[1] UNIV BASEL,BIOZENTRUM,ABT ZELLBIOL,CH-4056 BASEL,SWITZERLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(96)10030-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the synthesis of mRNA in the nucleus, 3'-ends are generated by endonucleolytic cleavage followed by polyadenylation. The machinery responsible for this simple reaction is surprisingly complex. In vitro reconstitution of 3'-end processing has demonstrated the importance of cooperative interactions in RNA recognition and catalysis. However, the inventory of processing factors is still incomplete and important mechanistic questions have not yet been answered.

引用

页码：247 / 250

页数：4

共 37 条

[1] BALLANTYNE S, 1995, RNA, V1, P64
[2] DEGRADATION OF MESSENGER-RNA IN EUKARYOTES
BEELMAN, CA
PARKER, R
[J]. CELL, 1995, 81 (02) : 179 - 183
[3] NUCLEAR POLYADENYLATION FACTORS RECOGNIZE CYTOPLASMIC POLYADENYLATION ELEMENTS
BILGER, A
FOX, CA
WAHLE, E
WICKENS, M
[J]. GENES & DEVELOPMENT, 1994, 8 (09) : 1106 - 1116
[4] THE HUMAN U1 SNRNP-SPECIFIC U1A PROTEIN INHIBITS POLYADENYLATION OF ITS OWN PREMESSENGER RNA
BOELENS, WC
JANSEN, EJR
VANVENROOIJ, WJ
STRIPECKE, R
MATTAJ, IW
GUNDERSON, SI
[J]. CELL, 1993, 72 (06) : 881 - 892
[5] NOVEL DROSOPHILA-MELANOGASTER GENES ENCODING RRM-TYPE RNA-BINDING PROTEINS IDENTIFIED BY A DEGENERATE PCR STRATEGY
BRAND, SF
PICHOFF, S
NOSELLI, S
BOURBON, HM
[J]. GENE, 1995, 154 (02) : 187 - 192
[6] CLEAVAGE SITE DETERMINANTS IN THE MAMMALIAN POLYADENYLATION SIGNAL
CHEN, F
MACDONALD, CC
WILUSZ, J
[J]. NUCLEIC ACIDS RESEARCH, 1995, 23 (14) : 2614 - 2620
[7] EGLI CM, 1995, MOL CELL BIOL, V15, P2466
[8] SEQUENCES HOMOLOGOUS TO 5' SPLICE SITES ARE REQUIRED FOR THE INHIBITORY ACTIVITY OF PAPILLOMAVIRUS LATE 3' UNTRANSLATED REGIONS
FURTH, PA
CHOE, WT
REX, JH
BYRNE, JC
BAKER, CC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) : 5278 - 5289
[9] CPSF RECOGNITION OF AN HIV-1 MESSENGER-RNA 3'-PROCESSING ENHANCER - MULTIPLE SEQUENCE CONTACTS INVOLVED IN POLY(A) SITE DEFINITION
GILMARTIN, GM
FLEMING, ES
OETJEN, J
GRAVELEY, BR
[J]. GENES & DEVELOPMENT, 1995, 9 (01) : 72 - 83
[10] THE HUMAN U1A SNRNP PROTEIN REGULATES POLYADENYLATION VIA A DIRECT INTERACTION WITH POLY(A) POLYMERASE
GUNDERSON, SI
BEYER, K
MARTIN, G
KELLER, W
BOELENS, WC
MATTAJ, IW
[J]. CELL, 1994, 76 (03) : 531 - 541

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