Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS

被引：465

作者：

Kimura, F ^{[1
]}

Fujimura, C ^{[1
]}

Ishida, S ^{[1
]}

Nakajima, H ^{[1
]}

Furutama, D ^{[1
]}

Uehara, H ^{[1
]}

Shinoda, K ^{[1
]}

Sugino, M ^{[1
]}

Hanafusa, T ^{[1
]}

机构：

[1] Osaka Med Coll, Dept Internal Med 1, Div Neurol, Osaka 5698686, Japan

来源：

NEUROLOGY | 2006年 / 66卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000194316.91908.8a

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors calculated the progression rate (Delta FS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the Delta FS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the Delta FS provides an additional predictive index beyond ALSFRS-R alone.

引用

页码：265 / 267

页数：3

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