Histone modifying enzymes: Structures, mechanisms, and specificities

被引：221

作者：

Marmorstein, Ronen ^{[2
,3
]}

Trievel, Raymond C. ^{[1
]}

机构：

[1] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

[2] Wistar Inst Anat & Biol, Program Gene Express & Regulat, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Chromatin; Transcription; Histone modification; Histone acetyltransferase; Histone demethylase; CATALYTIC MECHANISM; ANDROGEN-RECEPTOR; JMJD2; FAMILY; RAT-LIVER; H3; ACETYLTRANSFERASE; PROTEIN; DEMETHYLASE; GENE; ACETYLATION;

D O I：

10.1016/j.bbagrm.2008.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone modifying enzymes catalyze the addition or removal of an array of covalent modifications in histone and non-histone proteins. Within the context of chromatin, these modifications regulate gene expression as well as other genomic functions and have been implicated in establishing and maintaining a heritable epigenetic code that contributes to defining cell identity and fate. Biochemical and structural characterization of histone modifying enzymes has yielded important insights into their respective catalytic mechanisms, substrate specificities, and regulation. In this review, we summarize recent advances in understanding these enzymes, highlighting studies of the histone acetyltransferases (HATS) p300 (also now known as KAT3B) and Rtt109 (KAT11) and the histone lysine demethylases (HDMs) LSD1 (KDM1) and JMJD2A (KDM4A), present overriding themes that derive from these studies, and pose remaining questions concerning their regulatory roles in mediating DNA transactions. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：58 / 68

页数：11

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