Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

被引：256

作者：

Barouch, Dan H. ^{[1
,2
,3
]}

Alter, Galit ^{[2
,3
]}

Broge, Thomas ^{[2
,3
]}

Linde, Caitlyn ^{[2
,3
]}

Ackerman, Margaret E. ^{[4
]}

Brown, Eric P. ^{[1
,4
]}

Borducchi, Erica N. ^{[1
]}

Smith, Kaitlin M. ^{[1
]}

Nkolola, Joseph P. ^{[1
]}

Liu, Jinyan ^{[1
]}

Shields, Jennifer ^{[1
]}

Parenteau, Lily ^{[1
]}

Whitney, James B. ^{[1
]}

Abbink, Peter ^{[1
]}

Ng'ang'a, David M. ^{[1
]}

Seaman, Michael S. ^{[1
]}

Lavine, Christy L. ^{[1
]}

Perry, James R.

Li, Wenjun ^{[5
]}

Colantonio, Arnaud D. ^{[6
]}

Lewis, Mark G. ^{[7
]}

Chen, Bing ^{[8
]}

Wenschuh, Holger ^{[9
]}

Reimer, Ulf ^{[9
]}

Piatak, Michael ^{[10
]}

Lifson, Jeffrey D. ^{[10
]}

Handley, Scott A. ^{[11
]}

Virgin, Herbert W. ^{[11
]}

Koutsoukos, Marguerite ^{[12
]}

Lorin, Clarisse ^{[12
]}

Voss, Gerald ^{[12
]}

Weijtens, Mo ^{[13
]}

Pau, Maria G. ^{[13
]}

Schuitemaker, Hanneke ^{[13
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] MIT, Massachusetts Gen Hosp, Ragan Inst, Cambridge, MA 02139 USA

[3] Harvard Univ, Cambridge, MA 02139 USA

[4] Thayer Sch Engn Dartmouth, Hanover, NH 03755 USA

[5] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

[6] New England Primate Res Ctr, Southborough, MA 01772 USA

[7] Bioqual, Rockville, MD 20852 USA

[8] Childrens Hosp, Boston, MA 02115 USA

[9] JPT Peptide Technol GmbH, D-12489 Berlin, Germany

[10] Frederick Natl Lab, Leidos Biomed Res, AIDS & Canc Virus Program, Frederick, MD 21702 USA

[11] Washington Univ, Sch Med, St Louis, MO 63110 USA

[12] GSK Vaccines, B-1330 Rixensart, Belgium

[13] Janssen Infect Dis & Vaccines, NL-2301 Leiden, Netherlands

来源：

SCIENCE | 2015年 / 349卷 / 6245期

关键词：

IMMUNODEFICIENCY VIRUS-INFECTION; HIGHLY PATHOGENIC SIV; HIV-1; VACCINE; HIGH-THROUGHPUT; ANTIBODIES; RESPONSES; VECTORS; BREADTH;

D O I：

10.1126/science.aab3886

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Preclinical studies of viral vector-based HIV-1 vaccine candidates have previously shown partial protection against neutralization-resistant virus challenges in rhesus monkeys. In this study, we evaluated the protective efficacy of adenovirus serotype 26 (Ad26) vector priming followed by purified envelope (Env) glycoprotein boosting. Rhesus monkeys primed with Ad26 vectors expressing SIVsmE543 Env, Gag, and Pol and boosted with AS01B-adjuvanted SIVmac32H Env gp140 demonstrated complete protection in 50% of vaccinated animals against a series of repeated, heterologous, intrarectal SIVmac251 challenges that infected all controls. Protective efficacy correlated with the functionality of Env-specific antibody responses. Comparable protection was also observed with a similar Ad/Env vaccine against repeated, heterologous, intrarectal SHIV-SF162P3 challenges. These data demonstrate robust protection by Ad/Env vaccines against acquisition of neutralization-resistant virus challenges in rhesus monkeys.

引用

页码：320 / 324

页数：5

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