The Tau H1 haplotype is associated with Parkinson's disease in the Norwegian population

被引：55

作者：

Farrer, M

Skipper, L

Berg, M

Bisceglio, G

Hanson, M

Hardy, J

Adam, A

Gwinn-Hardy, K

Aasly, J ^{[1
]}

机构：

[1] Univ Trondheim Hosp, Dept Neurol, N-7006 Trondheim, Norway

[2] Mayo Clin, Lab Familial Movement Disorders, Jacksonville, FL 32224 USA

[3] NIA, Neurogenet Lab, Bethesda, MD 20892 USA

[4] NINCDS, Bethesda, MD 20892 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 322卷 / 02期

关键词：

Tau; genetics; Parkinson's disease; case-control study; epidemiology;

D O I：

10.1016/S0304-3940(02)00106-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio = 5.52; 95% confidence interval: 2.64-11.10; P = 2.17 X 10(-6)). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：83 / 86

页数：4

共 21 条

[1] Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies [J].

Arima, K ;

Hirai, S ;

Sunohara, N ;

Aoto, K ;

Izumiyama, Y ;

Uéda, K ;

Ikeda, K ;

Kawai, M .

BRAIN RESEARCH, 1999, 843 (1-2) :53-61

[2] Association of an extended haplotype in the tau gene with progressive supranuclear palsy [J].

Baker, M ;

Litvan, I ;

Houlden, H ;

Adamson, J ;

Dickson, D ;

Perez-Tur, J ;

Hardy, J ;

Lynch, T ;

Bigio, E ;

Hutton, M .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :711-715

[3] A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor [J].

Farrer, M ;

Gwinn-Hardy, K ;

Muenter, M ;

DeVrieze, FW ;

Crook, R ;

Perez-Tur, J ;

Lincoln, S ;

Maraganore, D ;

Adler, C ;

Newman, S ;

MacElwee, K ;

McCarthy, P ;

Miller, C ;

Waters, C ;

Hardy, J .

HUMAN MOLECULAR GENETICS, 1999, 8 (01) :81-85

[4] Lewy bodies and parkinsonism in families with parkin mutations [J].

Farrer, M ;

Chan, P ;

Chen, R ;

Tan, L ;

Lincoln, S ;

Hernandez, D ;

Forno, L ;

Gwinn-Hardy, K ;

Petrucelli, L ;

Hussey, J ;

Singleton, A ;

Tanner, C ;

Hardy, J ;

Langston, JW .

ANNALS OF NEUROLOGY, 2001, 50 (03) :293-300

[5] Diagnostic criteria for Parkinson disease [J].

Gelb, DJ ;

Oliver, E ;

Gilman, S .

ARCHIVES OF NEUROLOGY, 1999, 56 (01) :33-39

[6] The tau A0 allele in Parkinson's disease [J].

Golbe, LI ;

Lazzarini, AM ;

Spychala, JR ;

Johnson, WG ;

Stenroos, ES ;

Mark, MH ;

Sage, JI .

MOVEMENT DISORDERS, 2001, 16 (03) :442-447

[7] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[8] α-synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356 [J].

Jensen, PH ;

Hager, H ;

Nielsen, MS ;

Hojrup, P ;

Gliemann, J ;

Jakes, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (36) :25481-25489

[9]

Lazzarini AM, 1997, NEUROLOGY, V48, P6088

[10] The ubiquitin pathway in Parkinson's disease [J].

Leroy, E ;

Boyer, R ;

Auburger, G ;

Leube, B ;

Ulm, G ;

Mezey, E ;

Harta, G ;

Brownstein, MJ ;

Jonnalagada, S ;

Chernova, T ;

Dehejia, A ;

Lavedan, C ;

Gasser, T ;

Steinbach, PJ ;

Wilkinson, KD ;

Polymeropoulos, MH .

NATURE, 1998, 395 (6701) :451-452

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