Systemic therapeutic options for severe atopic dermatitis

被引：30

作者：

Bussmann, Caroline ^{[1
]}

Bieber, Thomas ^{[1
]}

Novak, Natalija ^{[1
]}

机构：

[1] Univ Bonn, Klin & Poliklin Dermatol & Allergol, D-53105 Bonn, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2009年 / 7卷 / 03期

关键词：

atopic dermatitis; systemic therapy; immunosuppressive drugs; antibiotics; immunotherapy; biologics; DOSE INTRAVENOUS IMMUNOGLOBULIN; ANTI-IGE THERAPY; DOUBLE-BLIND; IMMUNE GLOBULIN; NECK DERMATITIS; CYCLOSPORINE; ECZEMA; ADULT; METHOTREXATE; AZATHIOPRINE;

D O I：

10.1111/j.1610-0387.2008.06834.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Systemic therapy of severe atopic dermatitis (AD) is difficult in some cases, because the use of immunosuppressive agents such as cyclosporine A, mofetil mycophenolate, tacrolimus, and azathioprine is limited by adverse reactions or contraindications. Recent reports suggest a helpful role for biologics, methotrexate, anti-IgE antibodies, and immunotherapy. We review the modes of action, as well as advantages and disadvantages of current and new systemic therapeutic options for severe AD.

引用

页码：205 / 219

页数：15

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