Mechanism of free-radical generation by nitric oxide synthase

被引：120

作者：

Rosen, GM ^{[1
]}

Tsai, P

Pou, S

机构：

[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[2] Univ Maryland, Inst Biotechnol, Ctr Med Biotechnol, Baltimore, MD 21201 USA

[3] Univ Maryland, Ctr Low Frequency EPR Imaging In Vivo Physiol, Baltimore, MD 21093 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 04期

关键词：

D O I：

10.1021/cr010187s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An overview is given on the mechanism of free-radical generation by nitric oxide (NO) synthase. Topics discussed include the enzymology of nitric oxide synthase derived NO, superoxide generation by NO synthase, and secondary free-radical formation by NO synthase.

引用

页码：1191 / 1199

页数：9

共 107 条

[1] Stopped-flow analysis of substrate binding to neuronal nitric oxide synthase [J].

Abu-Soud, HM ;

Wang, JL ;

Rousseau, DL ;

Stuehr, DJ .

BIOCHEMISTRY, 1999, 38 (38) :12446-12451

[2] Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase [J].

Abu-Soud, HM ;

Ichimori, K ;

Presta, A ;

Stuehr, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17349-17357

[3] The ferrous-dioxy complex of neuronal nitric oxide synthase - Divergent effects of L-arginine and tetrahydrobiopterin on its stability [J].

AbuSoud, HM ;

Gachhui, R ;

Raushel, FM ;

Stuehr, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (28) :17349-17353

[4]

ABUSOUD HM, 1994, J BIOL CHEM, V269, P32047

[5] Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase - Implications for mechanism [J].

Adak, S ;

Wang, Q ;

Stuehr, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (43) :33554-33561

[6] SPIN-TRAPPING STUDIES OF PEROXYNITRITE DECOMPOSITION AND OF 3-MORPHOLINOSYDNONIMINE N-ETHYLCARBAMIDE AUTOOXIDATION - DIRECT EVIDENCE FOR METAL-INDEPENDENT FORMATION OF FREE-RADICAL INTERMEDIATES [J].

AUGUSTO, O ;

GATTI, RM ;

RADI, R .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 310 (01) :118-125

[7] Design of isoform-selective inhibitors of nitric oxide synthase [J].

Babu, BR ;

Griffith, OW .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (04) :491-500

[8] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[9] REACTION OF SUPEROXIDE WITH NITRIC-OXIDE TO FORM PEROXONITRITE IN ALKALINE AQUEOUS-SOLUTION [J].

BLOUGH, NV ;

ZAFIRIOU, OC .

INORGANIC CHEMISTRY, 1985, 24 (22) :3502-3504

[10] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685

← 1 2 3 4 5 6 7 8 9 10 →