Synthesis of base-modified noraristeromycin derivatives and their inhibitory activity against human and Plasmodium falciparum recombinant S-adenosyl-L-homocysteine hydrolase

被引：30

作者：

Kitade, Y ^{[1
]}

Kozaki, A ^{[1
]}

Miwa, T ^{[1
]}

Nakanishi, M ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Biomol Sci, Lab Mol Biochem, Gifu 5011193, Japan

来源：

TETRAHEDRON | 2002年 / 58卷 / 07期

关键词：

enzyme inhibitors; antivirals; nucleosides; hydrolysis; antiparasitics;

D O I：

10.1016/S0040-4020(01)01247-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Noraristeromycin derivatives possessing 2- or 8-position modified adenine or 8-aza-7-deazaadenine were synthesized, and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolases was investigated. Among these noraristeromycin derivatives, 2-aminonoraristeromycin selectively showed inhibitory activity against P. falciparum recombinant SAH hydrolase. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1271 / 1277

页数：7

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