Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors

被引：13

作者：

Bapma, A

Vickerstaffe, E

Warrington, BH

Ladlow, M

Fan, TPD

Ley, SV

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

[2] Univ Cambridge, Chem Lab, GlaxoSmithKline Cambridge Technol Ctr, Cambridge CB2 1EW, England

[3] Univ Cambridge, Chem Lab, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 04期

关键词：

D O I：

10.1039/b313414h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The polymer-assisted solution phase synthesis (PASP) of an array of historic deacetylase (HDAc) inhibitors is described. HDAc inhibitors have considerable potential as new anti-proliferative agents. Selected compounds were shown to inhibit both human endothelial cell proliferation, and the formation of tubules (neovascularisation) in an in vitro model of angiogenesis.

引用

页码：611 / 620

页数：10

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