Helicobacter pylori-induced gastritis may contribute to occurrence of postprandial symptomatic hypoglycemia

被引:10
作者
Açbay, O [1 ]
Çelik, AF
Kadioglu, P
Göksel, S
Gündogdu, S
机构
[1] Univ Istanbul, Cerrahpasa Med Sch Hosp, Div Endocrinol & Metab, Dept Internal Med, TR-34303 Aksaray Istanbul, Turkey
[2] Univ Istanbul, Cerrahpasa Med Sch Hosp, Div Gastroenterol, TR-34303 Aksaray Istanbul, Turkey
[3] Univ Istanbul, Cerrahpasa Med Sch Hosp, Dept Pathol, TR-34303 Aksaray Istanbul, Turkey
关键词
Helicobacter pylori; postprandial hypoglycemia; insulin secretion; gastrin;
D O I
10.1023/A:1018842606388
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In our clinical experience, postprandial symptomatic hypoglycemic (PSH) patients with H. pylori gastritis showed a substantial improvement in their hypoglycemic symptoms after the eradication of H. pylori. Therefore, in this study we have investigated whether H. pylori gastritis may contribute to the occurrence of PSH. For this purpose, we have evaluated the following parameters in 12 PSH patients with H. pylori gastritis before and one month after the eradication therapy: (1) the number and severity of PSH attacks that occurred in a one-month period using a 30-day diary, (2) the total symptom score following a mixed meal using a visual analog scale questionnaire (VASQ), and (3) the glucose and insulin responses to the mixed meal. After the eradication of H. pylori, the serum insulin responses at 30 and 60 min decreased (P < 0.001 in both), whereas the plasma glucose levels at 150, 180 and 210 min increased significantly (P < 0.001 for 180 min and P < 0.01 in others) following the mixed meal. The number and severity score of PSH attacks that occurred in a one-month period and the area under curve for symptom score in VASQ decreased significantly (P < 0.001 in all). These results suggest that H. pylori gastritis may contribute to the occurrence of PSH.
引用
收藏
页码:1837 / 1842
页数:6
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