A lysine walk to high relaxivity collagen-targeted MRI contrast agents

被引:24
作者
Caravan, Peter [1 ,2 ]
Das, Biplab [3 ]
Deng, Qing [3 ]
Dumas, Stephane [3 ]
Jacques, Vincent [3 ]
Koerner, Steffi K. [3 ]
Kolodziej, Andrew [3 ]
Looby, Richard J. [3 ]
Sun, Wei-Chuan [3 ]
Zhang, Zhaoda [3 ]
机构
[1] Massachusetts Gen Hosp, AA Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA
[3] Epix Pharmaceut, Lexington, MA 02140 USA
关键词
THROMBUS; MICE;
D O I
10.1039/b819098d
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
A strategy for preparing peptide-based magnetic resonance contrast agents with multiple gadolinium chelates is described.
引用
收藏
页码:430 / 432
页数:3
相关论文
共 16 条
[1]
Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI [J].
Amirbekian, Vardan ;
Lipinski, Michael J. ;
Briley-Saebo, Karen C. ;
Amirbekian, Smbat ;
Aguinaldo, Juan Gilberto S. ;
Weinreb, David B. ;
Vucic, Esad ;
Frias, Juan C. ;
Hyafil, Fabien ;
Mani, Venkatesh ;
Fisher, Edward A. ;
Fayad, Zahi A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :961-966
[2]
Collagen-targeted MRI contrast agent for molecular Imaging of fibrosis [J].
Caravan, Peter ;
Das, Biplab ;
Dumas, Stephane ;
Epstein, Frederick H. ;
Helm, Patrick A. ;
Jacques, Vincent ;
Koerner, Steffi ;
Kolodziej, Andrew ;
Shen, Luhua ;
Sun, Wei-Chuan ;
Zhang, Zhaoda .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (43) :8171-8173
[3]
Strategies for increasing the sensitivity of gadolinium based MRI contrast agents [J].
Caravan, Peter .
CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) :512-523
[4]
Solid-phase synthesis of DOTA-peptides [J].
De León-Rodriguez, LM ;
Kovacs, Z ;
Dieckmann, GR ;
Sherry, AD .
CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (05) :1149-1155
[5]
Magnetic resonance imaging detects a specific peptide-protein binding event [J].
De León-Rodríguez, LM ;
Ortiz, A ;
Weiner, AL ;
Zhang, SR ;
Kovacs, Z ;
Kodadek, T ;
Sherry, AD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (14) :3514-3515
[6]
Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes [J].
Erdogan, Suna ;
Medarova, Zdravka O. ;
Roby, Aruna ;
Moore, Anna ;
Torchilin, Vladimir P. .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2008, 27 (03) :574-580
[7]
Novel MRI contrast agent for molecular imaging of fibrin implications for detecting vulnerable plaques [J].
Flacke, S ;
Fischer, S ;
Scott, MJ ;
Fuhrhop, RJ ;
Allen, JS ;
McLean, M ;
Winter, P ;
Sicard, GA ;
Gaffney, PJ ;
Wickline, SA ;
Lanza, GM .
CIRCULATION, 2001, 104 (11) :1280-1285
[8]
Postinfarction myocardial scarring in mice: Molecular MR imaging with use of a collagen-targeting contrast agent [J].
Helm, Patrick A. ;
Caravan, Peter ;
French, Brent A. ;
Jacques, Vincent ;
Shen, Luhua ;
Xu, Yaqin ;
Beyers, Ronald J. ;
Roy, R. Jack ;
Kramer, Christopher M. ;
Epstein, Frederick H. .
RADIOLOGY, 2008, 247 (03) :788-796
[9]
Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice [J].
Kandimalla, Karunya K. ;
Wengenack, Thomas M. ;
Curran, Geoffry L. ;
Gilles, Emily J. ;
Poduslo, Joseph F. .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 322 (02) :541-549
[10]
Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent [J].
Krishnan, Anant S. ;
Neves, Andre A. ;
de Backer, Maaike M. ;
Hu, De-En ;
Davletov, Bazbek ;
Kettunen, Mikko I. ;
Brindle, Kevin M. .
RADIOLOGY, 2008, 246 (03) :854-862