Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis

被引：91

作者：

Sormani, MP

Rovaris, M

Valsasina, P

Wolinsky, JS

Comi, G

Filippi, M

机构：

[1] Inst Sci, Dept Neurol, Neuroimaging Res Unit, I-20132 Milan, Italy

[2] Inst Sci, Dept Neurol, Clin Trials Unit, I-20132 Milan, Italy

[3] Univ Osped San Raffaele, Milan, Italy

[4] Natl Inst Canc Res, Unit Clin Epidemiol & Trials, Genoa, Italy

[5] Univ Texas, Hlth Sci Ctr, Houston, TX USA

来源：

NEUROLOGY | 2004年 / 62卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000120663.85143.B3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage ( Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.

引用

页码：1432 / 1434

页数：3

共 9 条

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