Copper(II)/H2O2-mediated DNA cleavage:: Involvement of a copper(III) species in H-atom abstraction of deoxyribose units

被引：20

作者：

Amine, A

Atmani, Z

El Hallaoui, A

Giorgi, M

Pierrot, M

Réglier, M

机构：

[1] Univ Aix Marseille 1, CNRS, UMR 6517, Fac Sci & Tech St Jerome, F-13397 Marseille 20, France

[2] Univ Moulay Ismail, Fac Sci Meknes, Meknes, Morocco

[3] Univ Mohamed Benabdellah, Fac Sci & Tech Fes Sais, Fes, Morocco

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(01)00674-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new bis-amido-copper(II) complex 2 has been prepared. In the presence of reducing agents (ascorbate or DTT) under air atmosphere or hydrogen peroxide, complex 2 exhibited interesting nuclease activities in the 1-10 muM concentration range. For explaining the activity observed with hydrogen peroxide, we propose the occurrence of a bis-amido-copper(III) intermediate and an oxidation mechanism involving a H-atom abstraction of deoxyribose moieties of DNA. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：57 / 60

页数：4

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