Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol

被引：22

作者：

Cao, HY

Agrawal, D

Kushner, N

Touzjian, N

Essex, M

Lu, YC

机构：

[1] Calif Dept Hlth Serv, Viral & Rickettsial Dis Lab, Richmond, CA 94804 USA

[2] Massachusetts Gen Hosp, AIDS Res Ctr, Charlestown, MA USA

[3] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2002年 / 185卷 / 02期

关键词：

D O I：

10.1086/338448

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A fragment of anthrax lethal factor possesses the interesting function of delivering recombinant protein antigens through the classical major histocompatibility complex (MHC) class I pathway. This region of the lethal factor lacks the domain associated with anthrax cytotoxicity and functions independently of its binary partner, protective antigen. Experiments that used inhibitors at different steps of the MHC class I pathway supported this hypothesis. Application of this discovery to current T cell assays allows for the measurement of cytotoxic T lymphocyte function without resorting to live vectors and provides a useful new tool to design and test T cell-dependent vaccines.

引用

收藏

页码：244 / 251

页数：8

相关论文

共 41 条

[1]

ANDERSON KS, 1993, J IMMUNOL, V151, P3407

[2] EVIDENCE THAT TRANSPORTERS ASSOCIATED WITH ANTIGEN-PROCESSING TRANSLOCATE A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I-BINDING PEPTIDE INTO THE ENDOPLASMIC-RETICULUM IN AN ATP-DEPENDENT MANNER [J].

ANDROLEWICZ, MJ ;

ANDERSON, KS ;

CRESSWELL, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :9130-9134

[3] Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin [J].

Ballard, JD ;

Doling, AM ;

Beauregard, K ;

Collier, RJ ;

Starnbach, MN .

INFECTION AND IMMUNITY, 1998, 66 (02) :615-619

[4] Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo [J].

Ballard, JD ;

Collier, RJ ;

Starnbach, MN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) :12531-12534

[5] Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus [J].

Borrow, P ;

Lewicki, H ;

Wei, XP ;

Horwitz, MS ;

Peffer, N ;

Meyers, H ;

Nelson, JA ;

Gairin, JE ;

Hahn, BH ;

Oldstone, MBA ;

Shaw, GM .

NATURE MEDICINE, 1997, 3 (02) :205-211

[6] VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

BORROW, P ;

LEWICKI, H ;

HAHN, BH ;

SHAW, GM ;

OLDSTONE, MBA .

JOURNAL OF VIROLOGY, 1994, 68 (09) :6103-6110

[7] Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: Relevance to HIV-1 vaccine trials in Uganda [J].

Cao, HY ;

Mani, I ;

Vincent, R ;

Mugerwa, R ;

Mugyenyi, P ;

Kanki, P ;

Ellner, J ;

Walker, BD .

JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (05) :1350-1356

[8] Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: Implications for vaccine development [J].

Cao, HY ;

Kanki, P ;

Sankale, JL ;

DiengSarr, A ;

Mazzara, GP ;

Kalams, SA ;

Korber, B ;

Mboup, S ;

Walker, BD .

JOURNAL OF VIROLOGY, 1997, 71 (11) :8615-8623

[9] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor [J].

Duesbery, NS ;

Webb, CP ;

Leppla, SH ;

Gordon, VM ;

Klimpel, KR ;

Copeland, TD ;

Ahn, NG ;

Oskarsson, MK ;

Fukasawa, K ;

Paull, KD ;

Vande Woude, GF .

SCIENCE, 1998, 280 (5364) :734-737

[10] IDENTIFICATION OF NATURALLY PROCESSED VIRAL NONAPEPTIDES ALLOWS THEIR QUANTIFICATION IN INFECTED-CELLS AND SUGGESTS AN ALLELE-SPECIFIC T-CELL EPITOPE FORECAST [J].

FALK, K ;

ROTZSCHKE, O ;

DERES, K ;

METZGER, J ;

JUNG, G ;

RAMMENSEE, HG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (02) :425-434

← 1 2 3 4 5 →