Pathophysiology of Obesity-Related Renal Dysfunction Contributes to Diabetic Nephropathy

被引：40

作者：

Bayliss, George ^{[1
,2
]}

Weinrauch, Larry A. ^{[3
]}

D'Elia, John A. ^{[3
,4
]}

机构：

[1] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

[2] Rhode Isl & Miriam Hosp, Div Kidney Dis & Hypertens, Providence, RI USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Renal Unit, Boston, MA 02215 USA

来源：

CURRENT DIABETES REPORTS | 2012年 / 12卷 / 04期

关键词：

Obesity; Obstructive sleep apnea; Proteinuria; Insulin resistance; Podocyte; Nephrin; Adipocyte; Diabetes; Renal dysfunction; Diabetic nephropathy; OBSTRUCTIVE SLEEP-APNEA; CHRONIC KIDNEY-DISEASE; FETUIN-A; METABOLIC SYNDROME; WEIGHT-LOSS; ADIPONECTIN; ASSOCIATION; NEPHRIN; INSULIN; RISK;

D O I：

10.1007/s11892-012-0288-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies have demonstrated the role of insulin resistance in renal injury related to obesity, with hyperfiltration leading to glomerulomegaly in a pattern similar to that found in diabetic nephropathy. Similarities in the histologic patterns of damage from obesity and diabetes point to overlapping mechanisms of injury. In this review, we will examine the hormonal mechanisms, signaling pathways and injury patterns in renal injury resulting from obesity and attempt to draw conclusions on the reasons for these similarities.

引用

收藏

页码：440 / 446

页数：7

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