A novel approach to tricyclic pharmaceuticals via directed dilithiation of diaryl compounds

被引：11

作者：

Birman, VB ^{[1
]}

Chopra, A ^{[1
]}

Ogle, CA ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT CHEM,CHARLOTTE,NC 28223

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 29期

关键词：

D O I：

10.1016/0040-4039(96)01068-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tricyclic compounds were prepared using a novel approach based on the reaction between dilithio-diphenyl ether with appropriately substituted esters. The pharmaceutical drug, clopipazan, and its corresponding deschloro analog were synthesized utilizing this approach. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5073 / 5076

页数：4

共 10 条

[1] ELECTROPHILIC AROMATIC SUBSTITUTION .6. PROTODESILYLATION AND PROTODETRITIATION OF SOME OXYGEN-CONTAINING AND SULPHUR-CONTAINING AROMATIC COMPOUNDS AND OF DIPHENYLMETHANE - EVIDENCE FOR HYPERCONJUGATION [J].