Functional role of post-translational modifications of Sp1 in tumorigenesis

被引：81

作者：

Chang, Wen-Chang ^{[1
,2
,3
,4
,5
]}

Hung, Jan-Jong ^{[1
,2
,3
,4
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Inst Bioinformat & Biosignal Transduct, Tainan 701, Taiwan

[4] Natl Cheng Kung Univ, Ctr Infect Dis & Signal Transduct Res, Tainan 701, Taiwan

[5] Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2012年 / 19卷

关键词：

HISTONE DEACETYLASE INHIBITOR; BREAST-CANCER CELLS; TRANSCRIPTION FACTOR SP1; ESTROGEN-RECEPTOR-ALPHA; O-GLYCOSYLATION; GENE-TRANSCRIPTION; PANCREATIC-CANCER; CYCLE ARREST; DNA-BINDING; PHOSPHORYLATION;

D O I：

10.1186/1423-0127-19-94

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. Recent studies found that an increase in Sp1 transcriptional activity is associated with the tumorigenesis. Moreover, post-translational modifications of Sp1, including glycosylation, phosphorylation, acetylation, sumoylation, ubiquitination, and methylation, regulate Sp1 transcriptional activity and modulate target gene expression by affecting its DNA binding activity, transactivation activity, or protein level. In addition, recent studies have investigated several compounds with anti-cancer activity that could inhibit Sp1 transcriptional activity. In this review, we describe the effect of various post-translational modifications on Sp1 transcriptional activity and discuss compounds that inhibit the activity of Sp1.

引用

页数：7

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