Unravelling novel intracellular pathways in cell-based assays

被引：25

作者：

Giese, K

Kaufmann, J

Pronk, GJ

Klippel, A

机构：

[1] Atugen AG, D-13125 Berlin, Germany

[2] Atugen USA, Boulder, CO 80301 USA

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 03期

关键词：

D O I：

10.1016/S1359-6446(01)02126-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmaceutical industry is currently facing several challenges to identify and develop novel drug targets. Traditional drug discovery focussed on a small number of well-characterized gene products. Recently, this picture has changed with the completion of the draft sequence of the human genome, which has led to the identification of thousands of novel genes with unknown or poorly understood function. To cope with this overwhelming number of potential drug target candidates, new strategies for the elucidation of gene function, as well as their involvement in intracellular pathways, are required.

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页码：179 / 186

页数：8

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