Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus

被引：53

作者：

Parshikov, IA

Freeman, JP

Lay, JO

Beger, RD

Williams, AJ

Sutherland, JB ^{[1
]}

机构：

[1] US FDA, Natl Ctr Toxicol Res, Div Microbiol, Jefferson, AR 72079 USA

[2] US FDA, Natl Ctr Toxicol Res, Div Chem, Jefferson, AR 72079 USA

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 177卷 / 01期

关键词：

N-acetylation; biotransformation; ciprofloxacin; fluoroquinolone; Mucor ramannianus;

D O I：

10.1016/S0378-1097(99)00302-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3-quinolinecarboxylic acid. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：131 / 135

页数：5

共 22 条

[1]

BORNER K, 1990, ANAL DRUGS METABOLIT, P131

[2] Fluoroquinolones in animal health [J].