The regulation of growth hormone secretion

被引:18
作者
Cuttler, L [1 ]
机构
[1] CASE WESTERN RESERVE UNIV,RAINBOW BABIES & CHILDRENS HOSP,DEPT PHARMACOL,CLEVELAND,OH 44106
关键词
D O I
10.1016/S0889-8529(05)70340-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The regulation of growth hormone secretion involves finely balanced, multicomponent systems at organ and intracellular levels. Expanding knowledge of the physiology of growth hormone regulation in recent years has increased the understanding of the bases for growth hormone diseases. We now can identify several cellular loci that cause growth hormone deficiency or growth hormone excess. In addition, the increased understanding of growth hormone physiology has resulted in an expansion of potential therapies for growth disorders. This article reviews the physiology of growth hormone secretion at a system level and cellular level and discusses mechanisms by which growth hormone secretion is altered during health and disease.
引用
收藏
页码:541 / &
页数:32
相关论文
共 206 条
[1]   EFFECT OF ADMINISTRATION OF HUMAN GROWTH HORMONE ON PLASMA GROWTH HORMONE, CORTISOL, GLUCOSE, AND FREE FATTY ACID RESPONSE TO INSULIN - EVIDENCE FOR GROWTH HORMONE AUTOREGULATION IN MAN [J].
ABRAMS, RL ;
GRUMBACH, MM ;
KAPLAN, SL .
JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (04) :940-&
[2]   STIMULATION OF SOMATOSTATIN RELEASE INVITRO BY SYNTHETIC HUMAN GROWTH HORMONE-RELEASING FACTOR BY A NONDOPAMINERGIC MECHANISM [J].
AGUILA, MC ;
MCCANN, SM .
ENDOCRINOLOGY, 1985, 117 (02) :762-765
[3]   ARGININE STIMULATES GROWTH-HORMONE SECRETION BY SUPPRESSING ENDOGENOUS SOMATOSTATIN SECRETION [J].
ALBAROTH, J ;
MULLER, OA ;
SCHOPOHL, J ;
VONWERDER, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (06) :1186-1189
[4]  
[Anonymous], ENDOCRINOLOGIST
[5]  
ARIMURA A, 1994, PITUITARY GLAND, P217
[6]  
Asa Sylvia L., 1995, P3
[7]   EXPRESSION OF THE GROWTH HORMONE-RELEASING HORMONE GENE AND ITS PEPTIDE PRODUCT IN THE RAT OVARY [J].
BAGNATO, A ;
MORETTI, C ;
OHNISHI, J ;
FRAJESE, G ;
CATT, KJ .
ENDOCRINOLOGY, 1992, 130 (03) :1097-1102
[8]   INDEPENDENT EFFECTS OF GROWTH-HORMONE RELEASING-FACTOR ON GROWTH-HORMONE RELEASE AND GENE-TRANSCRIPTION [J].
BARINAGA, M ;
BILEZIKJIAN, LM ;
VALE, WW ;
ROSENFELD, MG ;
EVANS, RM .
NATURE, 1985, 314 (6008) :279-281
[9]   TRANSCRIPTIONAL REGULATION OF GROWTH-HORMONE GENE-EXPRESSION BY GROWTH HORMONE-RELEASING FACTOR [J].
BARINAGA, M ;
YAMONOTO, G ;
RIVIER, C ;
VALE, W ;
EVANS, R ;
ROSENFELD, MG .
NATURE, 1983, 306 (5938) :84-85
[10]  
BAUER FE, 1986, LANCET, V2, P192