Interpreting small differences in functional status: The six minute walk test in chronic lung disease patients

被引:714
作者
Redelmeier, DA
Bayoumi, AM
Goldstein, RS
Guyatt, GH
机构
[1] UNIV TORONTO,DEPT MED,PROGRAM CLIN EPIDEMIOL & HLTH CARE RES,TORONTO,ON,CANADA
[2] MCMASTER UNIV,DEPT CLIN EPIDEMIOL & BIOSTAT,HAMILTON,ON,CANADA
[3] MCMASTER UNIV,DEPT MED,HAMILTON,ON,CANADA
关键词
D O I
10.1164/ajrccm.155.4.9105067
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Functional status measurements ape often difficult to interpret because small differences may be statistically significant but not clinically significant, Mow much does the Six Minute Walk test (6MW) need to differ to signify a noticeable difference in walking ability for patients with chronic obstructive pulmonary disease (COPD)? We studied individuals with stable COPD (n = 112, mean age = Qa yr; mean FEV(1) = 975 mi) and estimated the smallest difference in 6MW distances that was associated with a noticeable difference in patients' subjective comparison ratings of their walking ability. We found that the 6MW was significantly correlated with patients' ratings cad their walking ability relative to other patients (r = 0.59, 95% confidence interval [CI]: 0.54 to 0.63). Distances needed to differ by 54 m for the average patient to stop rating themselves as ''about the same'' and start rating themselves as either ''a little bit better'' or ''a little bit worse'' (95% Cf: 37 to 71 m). We suggest that differences in functional status can be statistically significant but below the threshold at which patients notice a difference in themselves relative to others; an awareness of the smallest difference in walking distance that is noticeable to patients may help clinicians interpret the effectiveness of symptomatic treatments for COPD.
引用
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页码:1278 / 1282
页数:5
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