Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2

被引：185

作者：

Cardozo, Ludmila F. M. F. ^{[1
]}

Pedruzzi, Liliana M. ^{[1
]}

Stenvinkel, Peter ^{[2
]}

Stockler-Pinto, Milena B. ^{[3
]}

Daleprane, Julio B. ^{[4
]}

Leite Jr, Maurilo ^{[5
]}

Mafra, Denise ^{[1
]}

机构：

[1] Fed Fluminense Univ UFF, Grad Programme Cardiovasc Sci, Niteroi, RJ, Brazil

[2] Karolinska Inst, Div Renal Med, S-10401 Stockholm, Sweden

[3] Fed Univ Rio De Janeiro UFRJ, Inst Biophys Carlos Chagas Filho, Hlth Sci Ctr, Rio De Janeiro, Brazil

[4] State Univ Rio De Janeiro UERJ, Inst Nutr, Dept Basic & Expt Nutr, Rio De Janeiro, Brazil

[5] Fed Univ Rio De Janeiro UFRJ, Div Nephrol, Nephrol Integrated Ctr, Rio De Janeiro, Brazil

来源：

BIOCHIMIE | 2013年 / 95卷 / 08期

关键词：

Nutrients; Nrf2; Inflammation; Oxidative stress; NF-KAPPA-B; CISPLATIN-INDUCED NEPHROTOXICITY; NRF2/HO-1 SIGNALING PATHWAY; GLUTATHIONE-S-TRANSFERASE; NUCLEAR TRANSLOCATION; NF-E2-RELATED FACTOR; INSULIN-RESISTANCE; RESPONSE ELEMENT; HEME OXYGENASE-1; PROSTATE-CANCER;

D O I：

10.1016/j.biochi.2013.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where oxidative stress and inflammation are common conditions. The Nrf2 regulates the expression of detoxifying enzymes by recognizing the human Antioxidant Response Element (ARE) binding site and it can regulate antioxidant and antiinflammatory cellular responses, playing an important protective role on the development of the diseases. Studies designed to investigate how effective Nr12 activators or modulators are need to be initiated. Several recent studies have shown that nutritional compounds can modulate the activation of Nrf2-Keap1 system. This review aims to discuss some of the key nutritional compounds that promote the activation of Nr12, which may have impact on the human health. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：1525 / 1533

页数：9

共 124 条

[1]

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals [J].

Aggarwal, Bharat B. .

ANNUAL REVIEW OF NUTRITION, VOL 30, 2010, 30 :173-199

[2]

Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity [J].

Anderson, RA ;

Broadhurst, CL ;

Polansky, MM ;

Schmidt, WF ;

Khan, A ;

Flanagan, VP ;

Schoene, NW ;

Graves, DJ .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (01) :65-70

[3]

Appendino G, 2011, Panminerva Med, V53, P43

[4]

Arditti FD, 2005, MOL CANCER THER, V4, P325

[5]

After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult [J].

Arredondo, Florencia ;

Echeverry, Carolina ;

Abin-Carriquiry, Juan A. ;

Blasina, Fernanda ;

Antunez, Karina ;

Jones, Dean P. ;

Go, Young-Mi ;

Liang, Yong-Liang ;

Dajas, Federico .

FREE RADICAL BIOLOGY AND MEDICINE, 2010, 49 (05) :738-747

[6]

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation [J].

Bai, Yang ;

Cui, Wenpeng ;

Xin, Ying ;

Miao, Xiao ;

Barati, Michelle T. ;

Zhang, Chi ;

Chen, Qiang ;

Tan, Yi ;

Cui, Taixing ;

Zheng, Yang ;

Cai, Lu .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2013, 57 :82-95

[7]

The cytoprotective role of the Keap1-Nrf2 pathway [J].

Baird, Liam ;

Dinkova-Kostova, Albena T. .

ARCHIVES OF TOXICOLOGY, 2011, 85 (04) :241-272

[8]

γ-Tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice [J].

Barve, Avantika ;

Khor, Tin Oo ;

Nair, Sujit ;

Reuhl, Kenneth ;

Suh, Nanjoo ;

Reddy, Bandaru ;

Newmark, Harold ;

Kong, Ah-Ng .

INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (07) :1693-1699

[9]

Allicin Purified From Fresh Garlic Cloves Induces Apoptosis in Colon Cancer Cells Via Nrf2 [J].

Bat-Chen, Wolf ;

Golan, Tal ;

Peri, Irena ;

Ludmer, Zvi ;

Schwartz, Betty .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2010, 62 (07) :947-957

[10]

Beecher GR, 2003, J NUTR, V133, p3248S

← 1 2 3 4 5 6 7 8 9 10 →