Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines

被引：42

作者：

Alkhatib, Racha ^{[1
]}

Hennebelle, Thierry ^{[1
]}

Joha, Sami ^{[2
]}

Idziorek, Thierry ^{[2
]}

Preudhomme, Claude ^{[2
]}

Quesnel, Bruno ^{[2
]}

Sahpaz, Sevser ^{[1
]}

Bailleul, Francois ^{[1
]}

机构：

[1] Univ Lille 2, Lab Pharmacognosie, Fac Sci Pharmaceut & Biol, EA 1043, F-59006 Lille, France

[2] INSERM, Inst Rech Canc, Equipe 3, U837, F-59045 Lille, France

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 17期

关键词：

Ferula elaeochytris; Apiaceae; Sesquiterpene; Leukemia; Dasatinib; Imatinib;

D O I：

10.1016/j.phytochem.2008.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the roots of Ferula elaeochytris made it possible to isolate two sesquiterpene esters, 6-anthraniloyljaeschkeanadiol (elaeochytrin A) and 4 beta-hydroxy-6 alpha-(p-hydroxybenzoyloxy)dauc-9-ene (elaeochytrin B), as well as eight known compounds: 6-angeloyljaeschkeanadiol, teferidin, ferutinin, 6-(p-hydroxybenzoyl)epoxyjaeschkeanadiol, 6-(p-hydroxybenzoyl)lancerotriol, 5-caffeoylquinic acid, 1,5-dicaffeoylquinic acid and sandrosaponin IX. The cytotoxic activities of all compounds were investigated on K562R (imatinib-resistant) human chronic myeloid leukaemia and DA1-3b/M2(BCR-ABL) (dasatinib-resistant) mouse leukemia cell line. Elaeochytrin A was the most active compound on both cell lines (IC50 = 12.4 and 7.8 mu M, respectively). It was also tested on non-resistant human promyelocytic leukemia cells (HL60, IC50 = 13.1 mu M) and was not toxic to normal peripheral blood mononuclear cells up to 100 mu M. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2979 / 2983

页数：5

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