Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines

被引:42
作者
Alkhatib, Racha [1 ]
Hennebelle, Thierry [1 ]
Joha, Sami [2 ]
Idziorek, Thierry [2 ]
Preudhomme, Claude [2 ]
Quesnel, Bruno [2 ]
Sahpaz, Sevser [1 ]
Bailleul, Francois [1 ]
机构
[1] Univ Lille 2, Lab Pharmacognosie, Fac Sci Pharmaceut & Biol, EA 1043, F-59006 Lille, France
[2] INSERM, Inst Rech Canc, Equipe 3, U837, F-59045 Lille, France
关键词
Ferula elaeochytris; Apiaceae; Sesquiterpene; Leukemia; Dasatinib; Imatinib;
D O I
10.1016/j.phytochem.2008.09.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phytochemical investigation of the roots of Ferula elaeochytris made it possible to isolate two sesquiterpene esters, 6-anthraniloyljaeschkeanadiol (elaeochytrin A) and 4 beta-hydroxy-6 alpha-(p-hydroxybenzoyloxy)dauc-9-ene (elaeochytrin B), as well as eight known compounds: 6-angeloyljaeschkeanadiol, teferidin, ferutinin, 6-(p-hydroxybenzoyl)epoxyjaeschkeanadiol, 6-(p-hydroxybenzoyl)lancerotriol, 5-caffeoylquinic acid, 1,5-dicaffeoylquinic acid and sandrosaponin IX. The cytotoxic activities of all compounds were investigated on K562R (imatinib-resistant) human chronic myeloid leukaemia and DA1-3b/M2(BCR-ABL) (dasatinib-resistant) mouse leukemia cell line. Elaeochytrin A was the most active compound on both cell lines (IC50 = 12.4 and 7.8 mu M, respectively). It was also tested on non-resistant human promyelocytic leukemia cells (HL60, IC50 = 13.1 mu M) and was not toxic to normal peripheral blood mononuclear cells up to 100 mu M. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2979 / 2983
页数:5
相关论文
共 34 条
[1]   Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis [J].
Barthomeuf, Chantal ;
Lim, Suzanne ;
Iranshahi, Mehrdad ;
Chollet, Philippe .
PHYTOMEDICINE, 2008, 15 (1-2) :103-111
[2]   Conferone from Ferula schtschurowskiana enhances vinblastine cytotoxicity in MDCK-MDR1 cells by competitively inhibiting P-glycoprotein transport [J].
Barthomeuf, Chantal ;
Demeule, Michel ;
Grassi, Jerome ;
Saidkhodjaev, Ashraf ;
Beliveau, Richard .
PLANTA MEDICA, 2006, 72 (07) :634-639
[3]  
BIRNIE GD, 1988, BRIT J CANCER, V58, P41
[4]  
BUXERAUD J, 2008, ACTUAL PHARM, V471, P49
[5]   Epidemiology, medical demography and data quality issues in the former Soviet Union [J].
Chenet, L ;
Telishevska, M .
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2000, 54 (10) :722-723
[6]   Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat [J].
Colman-Saizarbitoria, Trina ;
Boutros, Paulo ;
Amesty, Angel ;
Bahsas, Ali ;
Mathison, Yaira ;
del Rosario Garrido, Maria ;
Israel, Anita .
JOURNAL OF ETHNOPHARMACOLOGY, 2006, 106 (03) :327-332
[7]   Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal [J].
Eigner, D ;
Scholz, D .
JOURNAL OF ETHNOPHARMACOLOGY, 1999, 67 (01) :1-6
[8]   CAROTANE SESQUITERPENES FROM FERULA-LANCEROTTENSIS [J].
FRAGA, BM ;
GONZALEZ, AG ;
GONZALEZ, P ;
HERNANDEZ, MG ;
LARRUGA, CL .
PHYTOCHEMISTRY, 1985, 24 (03) :501-504
[9]   Cancer chemopreventive activity of terpenoid Coumarins from Ferula species [J].
Iranshahi, Mehrdad ;
Kalategi, Farhad ;
Rezaee, Rannin ;
Shahverdi, Ahmad Reza ;
Ito, Chihiro ;
Furukawa, Hiroshi ;
Tokuda, Harukuni ;
Itoigawa, Masataka .
PLANTA MEDICA, 2008, 74 (02) :147-150
[10]   The MeOH extract of Pleurospermum kamtschaticum and its active component buddlejasaponin (IV) inhibits intrinsic and extrinsic hyperlipidemia and hypercholesterolemia in the rat [J].
Jung, Hyun-Ju ;
Nam, Jung-Hwan ;
Park, Hee-Juhn ;
Lee, Kyung-Tae ;
Park, Kwang-Kyun ;
Kim, Won-Bae ;
Choi, Jongwon .
JOURNAL OF ETHNOPHARMACOLOGY, 2007, 112 (02) :255-261